Histiocytic Diseases
Histiocytic Diseases Kenneth L. McClain Carl E. Allen John M. Hicks INTRODUCTION Histiocytic disorders are a group of diseases that are characterized by abnormal differentiation or function of “histiocytes.” Although…
Lymphoproliferative Disorders and Malignancies Related to Immunodeficiencies
Lymphoproliferative Disorders and Malignancies Related to Immunodeficiencies Robert J. Hayashi Birte Wistinghausen Bruce Shiramizu INTRODUCTION In 1959, Thomas conceptualized that the immune system played a role in oncogenesis. He hypothesized…
Malignant Non-Hodgkin Lymphomas in Children
Malignant Non-Hodgkin Lymphomas in Children Carl E. Allen Kala Y. Kamdar Catherine M. Bollard Thomas G. Gross INTRODUCTION Non-Hodgkin lymphoma (NHL) of childhood is a diverse collection of different lymphomas…
Hodgkin Lymphoma
Hodgkin Lymphoma Monika L. Metzger Matthew J. Krasin John K. Choi Melissa M. Hudson While the original paper by Hodgkin entitled “On Some Morbid Appearances of the Absorbent Glands and…
Myeloproliferative Neoplasms of Childhood
Myeloproliferative Neoplasms of Childhood Rachel Rau Mignon L. Loh Myeloproliferative neoplasms (MPNs) are a heterogeneous group of rare clonal hematopoietic stem cell disorders characterized by the abnormal proliferation of one…
Acute Myeloid Leukemia and Myelodysplastic Syndromes
Acute Myeloid Leukemia and Myelodysplastic Syndromes Robert J. Arceci Soheil Meshinchi HISTORICAL BACKGROUND AND DEFINITIONS The myeloid malignancies represent a heterogeneous group of acute and chronic clonal disorders that arise…
Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia Karen R. Rabin Maria M. Gramatges Judith F. Margolin David G. Poplack INTRODUCTION Advances in the study and treatment of pediatric acute lymphoblastic leukemia (ALL) are often…
Maximizing Safety in Cancer Treatment
Maximizing Safety in Cancer Treatment Brigitta U. Mueller Amy L. Billett INTRODUCTION In 1980, the American Society of Anesthesiologists was the first professional group to form a patient safety committee…
Cancer Clinical Trials: Design, Conduct, Analysis, and Reporting
Cancer Clinical Trials: Design, Conduct, Analysis, and Reporting Susan G. Hilsenbeck Lisa R. Bomgaars Stacey L. Berg Outcomes for many forms of childhood cancer have improved greatly over the past…
Hematopoietic Stem Cell Transplantation in Pediatric Oncology
Hematopoietic Stem Cell Transplantation in Pediatric Oncology Stephen Gottschalk Swati Naik Meenakshi Hegde Catherine M. Bollard Robert A. Krance Helen E. Heslop INTRODUCTION Hematopoietic stem cell transplantation (HSCT) is an…
