Hot Flashes
Hot Flashes Kunal C. Kadakia Charles L. Loprinzi Menopause can be associated with multiple adverse symptoms, including vasomotor instability, urinary incontinence, sexual dysfunction, depression, and insomnia. Vasomotor instability is a…
Fever and Sweats
Fever and Sweats James F. Cleary TEMPERATURE AND ASSOCIATED SYMPTOMS Temperature has long been used in clinical medicine and was included in the cardinal signs of inflammation described as “tumor,…
Cancer-Related Fatigue
Cancer-Related Fatigue Xin-Shelley Wang INTRODUCTION Cancer-related fatigue (CRF) is one of the most prevalent symptoms reported by cancer patients and survivors—and one that presents many challenges. Most epidemiologic studies of…
Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy Xiao-Min Wang Jane M. Fall-Dickson Tanya J. Lehky INTRODUCTION Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of taxanes, platinum compounds, vinca alkaloids,…
Pathology of Bone Metastases— Implications for Treatment
Pathology of Bone Metastases— Implications for Treatment Patrick W. Mantyh INTRODUCTION Similar to cancer itself, the factors that drive cancer pain evolve and change with disease progression. Surgery, radiation, and…
Interventional Approaches to Pain
Interventional Approaches to Pain Andrew Mannes Philip S. Kim Russell R. Lonser Interventional and neurosurgical procedures can be utilized to supplement pharmacologic and complementary approaches in the treatment of pain…
Nonpharmacologic Management of Pain
Nonpharmacologic Management of Pain Gayle L. Byker Dona Leskuski Arecent meta-analysis revealed that 64% of patients with cancer experience pain (1). Medications are currently the mainstay of treatment for cancer…
Opioid Pharmacotherapy
Opioid Pharmacotherapy Judith A. Paice Opioids and their derivatives have been used to relieve pain for centuries, and their contribution to relief of suffering is well established. Many of the…
Difficult Pain Syndromes: Neuropathic Pain, Bone Pain, and Visceral Pain
Difficult Pain Syndromes: Neuropathic Pain, Bone Pain, and Visceral Pain Lauren Shaiova Leonard A. Farber Sunil Kumar Aggarwal Nociception is what occurs physiologically in our bodies during the activation and…
