SYNTHESIS AND PROCESSING OF PROOPIOMELANOCORTIN Part of “CHAPTER 14 – ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS“ When ACTH is synthesized in the anterior pituitary gland by the corticotropes, it is derived…
ADRENOCORTICOTROPIN: PHYSIOLOGY AND CLINICAL ASPECTS David J. Torpy Richard V. Jackson The existence of an adrenocorticotropic factor was predicted by classic pituitary ablation/pituitary extract replacement experiments.1,2 Ovine and human adrenocorticotropin…
PREGNANCY AND PROLACTINOMAS Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ Many women with hyperprolactinemia present with infertility; bromocriptine is typically used to normalize prolactin levels and allow normal…
MANAGEMENT OF MACROPROLACTINOMAS Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ Unlike patients with microprolactinomas, those with macropro-lactinomas always require therapy. Patients with macroade-nomas may have evidence of local…
TREATMENT FOR PROLACTINOMAS Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ Treatment depends on whether the patient has hyperpro-lactinemia due to an underlying cause such as drugs or hypothyroidism,…
DIFFERENTIAL DIAGNOSIS AND CLINICAL APPROACH TO HYPERPROLACTINEMIA Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ As shown in Table 13-1 and Table 13-2, hyperprolactinemia has multiple causes. The measurement…
CLINICAL MANIFESTATIONS OF HYPERPROLACTINEMIA Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ The amenorrhea-galactorrhea syndrome is the classic description of the clinical manifestation of hyperprolactinemia. However, a spectrum of…
CLINICAL ASPECTS OF PROLACTIN PHYSIOLOGY Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ The physiologic causes of hyperprolactinemia are summarized in Table 13-1. The following sections describe clinical aspects…
NORMAL CONTROL OF PROLACTIN SECRETION Part of “CHAPTER 13 – PROLACTIN AND ITS DISORDERS“ Prolactin secretion is controlled by dual inhibitory and stimula-tory factors (Fig. 13-1). This hormone is unique…
PROLACTIN AND ITS DISORDERS Laurence Katznelson Anne Klibanski NORMAL CONTROL OF PROLACTIN SECRETION CLINICAL ASPECTS OF PROLACTIN PHYSIOLOGY CLINICAL MANIFESTATIONS OF HYPERPROLACTINEMIA Related posts: DIABETES INSIPIDUS REPRESSION OF BASAL TRANSCRIPTION/COREPRESSORS…
