HYPOPITUITARISM Joseph J. Pinzone The pituitary gland comprises anterior and posterior divisions. The anterior pituitary gland secretes adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth…
GONADOTROPE ADENOMAS OF THE PITUITARY Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ Many pituitary adenomas, previously classified as nonfunctional, produce gonadotropins or their subunits.79 Indeed, as many…
GONADAL EFFECTS OF GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ The only known bioeffects of LH and FSH are in the gonads. LH and FSH stimulate…
LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN PERIPHERAL BLOOD Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ LH and FSH circulate in blood predominantly in the monomeric form found…
EFFECTS OF GONADAL HORMONES ON GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ GONADAL STEROIDS Gonadal steroids and proteins exert direct pituitary effects on gonadotropin secretion along…
THERAPEUTIC USEFULNESS OF LUTEINIZING HORMONE–RELEASING HORMONE Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ GnRH and its agonist analogs are important in the treatment of GnRH deficiency states,…
STRUCTURE, SYNTHESIS, AND STORAGE OF GONADOTROPINS Part of “CHAPTER 16 – PITUITARY GONADOTROPINS AND THEIR DISORDERS“ SUBUNIT COMPOSITION The α and β subunit structure of LH and FSH1,2 is similar…
PITUITARY GONADOTROPINS AND THEIR DISORDERS William J. Bremner Ilpo Huhtaniemi John K. Amory The gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are large glycoproteins secreted from the anterior pituitary…
CLINICAL USE OF RECOMBINANT HUMAN THYROID-STIMULATING HORMONE Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ Recombinant human TSH has been produced by cotransfecting Chinese hamster ovary cells with…
DISORDERS OF THYROID-STIMULATING HORMONE CONTROL Part of “CHAPTER 15 – THYROID-STIMULATING HORMONE AND ITS DISORDERS“ DISORDERS CAUSING HYPOTHYROIDISM CENTRAL HYPOTHYROIDISM Central hypothyroidism results from failure of the pituitary to secrete…
