Oncohema Key

CLINICAL FORMS OF RESISTANCE TO THYROID HORMONE Part of “CHAPTER 32 – THYROID HORMONE RESISTANCE SYNDROMES“ In 1967, a bizarre finding in two young deaf-mute patients was reported by Refetoff…

MODEL OF THYROID-HORMONE RECEPTOR ACTION Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ On the basis of these findings, a model for the mechanism of…

TRANSCRIPTIONAL ACTIVATION BY THYROID HORMONE COACTIVATORS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Many factors potentially can modulate TH-mediated transcription. These include variability among…

REPRESSION OF BASAL TRANSCRIPTION/COREPRESSORS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Unliganded TRs bind to TREs and can repress transcription of positively regulated target…

THYROID HORMONE RESPONSE ELEMENTS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ TRs are ligand-dependent transcription factors that bind to distinct DNA sequences, generally in…

THYROID-HORMONE RECEPTORS AND THEIR STRUCTURE Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Two related TRs, which have been identified, bind TH with high affinity…

TARGET GENE REGULATION BY THYROID HORMONE Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ The effects of thyroid hormone (TH; L-thyroxine, T4; L-triiodo-thyronine, T3) on…