THYROTROPIN RECEPTOR ANTIBODIES Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ Certain thyroid disorders have been associated with an immunologic abnormality. Early bioassays, such as the long-acting thyroid stimulator and…
THYROID HORMONE ANTIBODIES Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ Occasional patients have autoantibodies to T4, T3, or both.27,31,32 Depending on the method used to separate bound from free…
THYROID PEROXIDASE ANTIBODIES Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ Patients with autoimmune thyroid disease commonly develop antibodies to thyroid antigens. Thyroid microsomal antibodies frequently are present in patients…
THYROGLOBULIN AND THYROGLOBULIN ANTIBODIES Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ Serum thyroglobulin (Tg) measurements are useful in the follow-up of patients with thyroid cancer28,29 (see Chap. 40). Numerous…
THYROTROPIN Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ Serum thyrotropin (thyroid-stimulating hormone, TSH) has been a reliable indicator of primary hypothyroidism, with levels rising even when thyroid deficiency is…
SERUM BINDING PROTEINS Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ Thyroid hormones are bound to three circulating proteins: thyroxine-binding globulin (TBG); TBPA, or TTR; and albumin. Routine serum T4…
IODOTHYRONINES Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ PROTEIN BOUND CONCENTRATIONS Serum thyroxine (T4) concentration was, for many years, the most useful first-line test of thyroid function. Historically, T4…
THYROID FUNCTION TESTS Robert C. Smallridge The determination of circulating levels of thyroid hormones is essential for an accurate assessment of the functional status of patients. By means of specific…
TREATMENT CONSIDERATIONS FOR THYROID HORMONE RESISTANCE Part of “CHAPTER 32 – THYROID HORMONE RESISTANCE SYNDROMES“ The diagnosis of generalized resistance or selective pituitary resistance to thyroid hormone does have a…
GENETIC MUTATIONS IN THYROID HORMONE RESISTANCE SYNDROMES Part of “CHAPTER 32 – THYROID HORMONE RESISTANCE SYNDROMES“ Generalized resistance to thyroid hormone is a genetic disease. Most reported cases belong to…
