DIFFERENTIAL DIAGNOSIS
DIFFERENTIAL DIAGNOSIS Part of “CHAPTER 58 – PRIMARY HYPERPARATHYROIDISM“ The differential diagnosis of hypercalcemia is covered in Chapter 59, but several points are particularly relevant to the discussion of primary…
LABORATORY EVALUATION
LABORATORY EVALUATION Part of “CHAPTER 58 – PRIMARY HYPERPARATHYROIDISM“ The diagnosis of primary hyperparathyroidism depends on laboratory tests. The serum calcium concentration is virtually always elevated. The serum phosphorus value…
CLINICAL PRESENTATION
CLINICAL PRESENTATION Part of “CHAPTER 58 – PRIMARY HYPERPARATHYROIDISM“ Patients with primary hyperparathyroidism may present with one of several clinical pictures: asymptomatic hypercalcemia; bone or stone disease; other recognized complications,…
CLINICAL MANIFESTATIONS
CLINICAL MANIFESTATIONS Part of “CHAPTER 58 – PRIMARY HYPERPARATHYROIDISM“ The signs and symptoms of primary hyperparathyroidism result from the hypercalcemia (see Chap. 59) and the hyperparathyroid state. In primary hyperparathyroidism,…
PATHOPHYSIOLOGY
PATHOPHYSIOLOGY Part of “CHAPTER 58 – PRIMARY HYPERPARATHYROIDISM“ The functional abnormality of primary hyperparathyroidism is incompletely understood. Normally, PTH secretion is tightly regulated by the serum ionized calcium concentration; it…
PRODUCTION AND METABOLISM OF VITAMIN D
PRODUCTION AND METABOLISM OF VITAMIN D Part of “CHAPTER 54 – VITAMIN D“ PHOTOPRODUCTION Technically, vitamin D3 is not a true vitamin because it can be produced in the body….
PRIMARY HYPERPARATHYROIDISM
PRIMARY HYPERPARATHYROIDISM Shonni J. Silverberg John P. Bilezikian Primary hyperparathyroidism is caused by excessive, abnormally regulated secretion of parathyroid hormone (PTH) from the parathyroid glands. Chronic exposure of its two…
