Oncohema Key

CORTICOSTEROID THERAPY Lloyd Axelrod This chapter examines the risks associated with the use of glucocorticoids and of mineralocorticoids for various illnesses, and provides guidelines for the administration of these commonly…

CONCLUSION Part of “CHAPTER 77 – CONGENITAL ADRENAL HYPERPLASIA“ Related posts: DEFINITIONS THYROID-HORMONE RECEPTOR BINDING TO THYROID HORMONE RESPONSE ELEMENTS DISEASE-SPECIFIC VARIATION RADIATION AND THYROID CARCINOMA PHYSICAL EXAMINATION AND MENSURATION…

OTHER GENETIC DISORDERS RELATED TO CONGENITAL ADRENAL HYPERPLASIA Part of “CHAPTER 77 – CONGENITAL ADRENAL HYPERPLASIA“ Several other disorders involve adrenal steroid-synthesizing enzymes. Strictly speaking, the CMO deficiencies and other…

GENETICS Part of “CHAPTER 77 – CONGENITAL ADRENAL HYPERPLASIA“ The autosomal recessive mode of inheritance of adrenal steroidogenic defects was recognized in the early 1950s.62,63 and 64 The linkage of…

TREATMENT Part of “CHAPTER 77 – CONGENITAL ADRENAL HYPERPLASIA“ Patients with simple virilizing or salt-wasting classic 21-hydroxylase deficiency or those with 11β-hydroxylase, 17α-hydroxylase/17,20-lyase, and 3β-HSD deficiencies, as well as select…

DIAGNOSIS Part of “CHAPTER 77 – CONGENITAL ADRENAL HYPERPLASIA“ POSTNATAL DIAGNOSIS The diagnosis of 21-hydroxylase deficiency may be confirmed by administering an intravenous bolus of ACTH and measuring the resultant…

EMBRYOLOGY Part of “CHAPTER 77 – CONGENITAL ADRENAL HYPERPLASIA“ The fetal gonads remain undifferentiated until about the seventh week of gestation (see Chap. 90). At that time, in normal 46,XY…

TREATMENT Part of “CHAPTER 76 – ADRENOCORTICAL INSUFFICIENCY“ The treatment of adrenal insufficiency consists of replacing the missing hormones.45 The treatment of an adrenal crisis theoretically would require administration of…