Fig. 6.1 Canonical and alternative miRNA biogenesis pathways. Most miRNA are transcribed by RNA Polymerase II to form long primary transcripts (pri-miRNA) which form complex structures that are then recognized…
Fig. 12.1 Overview of steroidogenesis. Tropic hormones bind to their respective G protein-coupled receptors leading to activation of the cAMP-PKA signaling cascade which in turn induces acute and/or chronicle effects…
Fig. 10.1 mTORC1 couples leptin secretion to the adipocyte size. Insulin and nutrients activate leptin biosynthesis via the mTORC1-mediated pathway that also promotes storage of triglycerides and increases the size…
Fig. 14.1 BDNF signaling impacts biological processes throughout the human body. BDNF binds to the TrkB receptor, resulting in receptor dimerization and autophosphorylation. Binding to the TrkB receptor activates multiple…
