Fig. 4.1 LHR mRNA levels during hCG-induced downregulation. Northern blot analysis of steady state LHR mRNA levels in total RNA, isolated at the indicated times, from the ovaries of saline-injected…
Fig. 13.1 Mechanisms of GC action discussed in this review. GCs exert their anti-inflammatory action through multiple mechanisms mediating coordinate changes in gene expression (see text). Regulation of inflammatory responses…
Fig. 1.1 Translation initiation and common mechanisms of regulation. The steps of translation initiation are outlined in (a). The ternary complex is comprised of eIFs 1, 1A, 3 and 5…
Fig. 11.1 Calcium , phosphate , PTH, FGF23, 1,25D and FGF23 interactions. There are endocrinological feedback loops that govern mineral homeostasis. FGF23, fibroblast growth factor 23; PTH, parathyroid hormone ,…
Fig. 2.1 Schematic representation of the human insulin (a) and mouse insulin 2 (b) genes. The both genes consist of three exons (boxes), and two introns (lines). The coding region…
Gene name 3′UTR miR sites References NR3A1/ESR1 4307 b Let-7 Manavathi et al. (2013) miR-137 Zhao et al. (2008) Zhao et al. (2008) Zhao et al. (2008) miR-145 miR-17-5p miR-18a/19b/20b…
Fig. 9.1 Overview of the PGE2 synthesis pathway. Arachidonic acid is liberated from phospholipids by phospholipase A2 and phospholipase C activity. Free arachidonic acid can then be converted into the…
Fig. 3.1 The role of cytokines in mediating communication between immune cells. Transcripts in grey are cytokine transcripts that contain AREs in their 3′UTRs . Transcripts labeled with an asterisk…
Family of RBPs C. elegans D. melanogaster X. laevis M. musculus H. sapiens PUF Fbf-1 Pum Pum1 PUM1 PUM1 Fbf-2 Pum2 PUM2 PUM2 Puf-8 Nanos Nos-3 Nos Nanos1 Nanos2 NANOS2…
Fig. 8.1 Human VEGFA gene structure and exon composition of the isoforms generated by alternative splicing . (Top) The human VEGFA gene spans 16,272 bp of chromosome 6p21.1 and consists…
