Modeling Cancer Metastasis
Fig. 7.1 A model of PCa progression. PCa starts as a localized tumor. In its natural progression, it typically metastasizes to the lymph nodes and then the bone, producing bone-forming…
Using PDX for Biomarker Development
Fig. 9.1 Biomarker Classification. Adapted from Mishra A, Verma M. Cancer biomarkers: are we ready for the prime time? Cancers. 2010;2(1):190–208. doi:10.3390/cancers2010190 DNA Biomarkers The most fundamental event in the…
Patient-Derived Tumor Xenografts: Historical Background
© Springer International Publishing AG 2017Yuzhuo Wang, Dong Lin and Peter W. Gout (eds.)Patient-Derived Xenograft Models of Human Cancer Molecular and Translational Medicine10.1007/978-3-319-55825-7_1 1. Patient-Derived Tumor Xenografts: Historical Background Dong Lin1, 2, 3 , Xinya Wang1, Peter W. Gout4, 3 and…
Towards Best Practice in Establishing Patient-Derived Xenografts
Fig. 2.1 Overview of the main steps in establishing PDXs. Step 1: High-quality patient specimens are obtained from various stages of cancer progression, from benign tissue to metastases, using a…
Studies of Cancer Heterogeneity Using PDX Models
Fig. 5.1 Efficacy study of S-1 in four gastric PDX models. a and b show that GAPF155 and GAPF157 were sensitive to S-1; c and d show that GAPF161 and…
