Fig. 12.1 Panel (a) illustrates the pattern of spontaneous systemic metastases that can arise heterogeneously in mice within a month or more after surgical resection of an established primary orthotopic…
Fig. 11.1 Schema for testing agents through the Pediatric Pre-clinical Testing Program (PPTP). Adapted from reference [68] Standard Cytotoxic Agents Responses to standard cytotoxic agents (vincristine, cyclophosphamide, actinomycin D, cisplatinum,…
Fig. 19.1 Representative image of a spheroid showing the key features. MCF7 cells seeded at 5000 cells per well in a 96-well ULA plate exhibited a tight spheroid after 96…
Fig. 15.1 (a) Human pancreatic-cancer-patient tumor with RFP and GFP stromal cells. Image was obtained with the Olympus FV1000. Green arrows indicate GFP stromal cells from GFP mouse. Red arrows…
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_21 21. Afterward: The Future of Patient-Derived Models of Cancer Robert M. Hoffman1, 2 (1) AntiCancer, Inc., 7917 Ostrow Street,…
Fig. 8.1 Three unique PDX models of early-stage, well-differentiated, androgen-responsive prostate cancer, respectively, all expressing AR and PSA [22, 37] The significant expansion of the number of PDXs for prostate…
Fig. 20.1 Drug efficacy testing in the PDOX model of HER-2-expressing cervical carcinoma. PDOX nude mice were treated with saline, carboplatin, trastuzumab + lapatinib, trastuzumab + lapatinib + entinostat, or…
Fig. 13.1 Patient sarcomas and melanomas were obtained at surgery, established in nude mice and subsequently implanted orthotopically in nude mice and treated with drugs indicated [26, 27, 30–34, 57]….
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_2 2. The Revival of Patient-Derived Xenograft Mouse Models of Cancer: Way Back to the Future Robert M. Hoffman1, 2 …
Fig. 10.1 Drug-efficacy testing in the PDOX model. PDOX nude mice were treated with saline, carboplatin, trastuzumab + lapatinib, trastuzumab + lapatinib + entinostat, or entinostat alone. (a) Bar graphs…
