Fig. 12.1 Panel (a) illustrates the pattern of spontaneous systemic metastases that can arise heterogeneously in mice within a month or more after surgical resection of an established primary orthotopic…
Fig. 11.1 Schema for testing agents through the Pediatric Pre-clinical Testing Program (PPTP). Adapted from reference [68] Standard Cytotoxic Agents Responses to standard cytotoxic agents (vincristine, cyclophosphamide, actinomycin D, cisplatinum,…
Fig. 19.1 Representative image of a spheroid showing the key features. MCF7 cells seeded at 5000 cells per well in a 96-well ULA plate exhibited a tight spheroid after 96…
Fig. 15.1 (a) Human pancreatic-cancer-patient tumor with RFP and GFP stromal cells. Image was obtained with the Olympus FV1000. Green arrows indicate GFP stromal cells from GFP mouse. Red arrows…
Fig. 8.1 Three unique PDX models of early-stage, well-differentiated, androgen-responsive prostate cancer, respectively, all expressing AR and PSA [22, 37] The significant expansion of the number of PDXs for prostate…
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_21 21. Afterward: The Future of Patient-Derived Models of Cancer Robert M. Hoffman1, 2 (1) AntiCancer, Inc., 7917 Ostrow Street,…
Fig. 20.1 Drug efficacy testing in the PDOX model of HER-2-expressing cervical carcinoma. PDOX nude mice were treated with saline, carboplatin, trastuzumab + lapatinib, trastuzumab + lapatinib + entinostat, or…
Fig. 13.1 Patient sarcomas and melanomas were obtained at surgery, established in nude mice and subsequently implanted orthotopically in nude mice and treated with drugs indicated [26, 27, 30–34, 57]….
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_2 2. The Revival of Patient-Derived Xenograft Mouse Models of Cancer: Way Back to the Future Robert M. Hoffman1, 2 …
Fig. 10.1 Drug-efficacy testing in the PDOX model. PDOX nude mice were treated with saline, carboplatin, trastuzumab + lapatinib, trastuzumab + lapatinib + entinostat, or entinostat alone. (a) Bar graphs…
