Cellular and Molecular Biology
Cellular and Molecular Biology Matthew J. Allen The Cell Cycle The transformation from a fertilized egg to a complex multi-cellular organism, be it a mouse or a human, depends on…
Soft Tissue Sarcomas
Soft Tissue Sarcomas Carol D. Morris Soft tissue sarcomas are malignant neoplasms that arise in nonepithelial extraskeletal tissue (e.g., fat, muscle, fibrous structures, etc.) of mesenchymal origin. They account for…
Metabolic Bone Diseases
Metabolic Bone Diseases Susan V. Bukata Metabolic bone diseases include a variety of diseases that affect the strength and overall quality of bones. Some of these diseases affect a huge…
Metastatic Disease
Metastatic Disease Timothy A. Damron Metastatic disease to bone accounts for the largest number of bone lesions in patients greater than 40 years of age. In fact, the differential diagnosis…
Hematologic Malignancies
Hematologic Malignancies Valerae O. Lewis Hematologic malignancies such as lymphoma and myeloma can manifest in bone, and these osseous manifestations can often be the first presentation of the systemic disease….
Werner Syndrome
Werner Syndrome Kathryn Palomino Werner syndrome is a rare hereditary systemic disease, also known as adult progeria. It is characterized by signs of premature aging (gray hair, skin changes, and…
Rothmund-Thomson Syndrome
Rothmund-Thomson Syndrome Kathryn Palomino Rothmund-Thomson syndrome is an autosomal recessive congenital syndrome (Box 7.5-1) associated with potential development of osteosarcoma. Since the patient usually arrives in the orthopaedic surgeon’s office…
Retinoblastoma Syndrome
Retinoblastoma Syndrome Timothy A. Damron Retinoblastoma syndrome encompasses familial retinoblastoma and a number of secondary malignancies that may develop as a result of a “second hit” at the site of…
Skeletal Dysplasias
Skeletal Dysplasias Danielle A. Katz Polyostotic Fibrous Dysplasia and Albright’s Syndrome Fibrous dysplasia is a condition in which there is fibro-osseous tissue in place of normal lamellar bone. Most often…
Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann Syndrome Danielle A. Katz Beckwith-Wiedemann syndrome is defined by the presence of macroglossia, omphalocele, and visceromegaly. Typically these children are seen by an orthopaedic surgeon for hemihypertrophy and/or cerebral…
