Omics of Chemoresistant and Metastatic Breast Cancer

Feb 12, 2017 by in ONCOLOGY Comments Off on Omics of Chemoresistant and Metastatic Breast Cancer

  Luminal A Luminal B Basal-like or TNCB HER2/ErbB2 Normal-like Claudin-low Genetic signature Luminal A (estrogen receptor positive and/or progesterone receptor positive, HER2 negative) Luminal B (estrogen receptor positive and/or…

read more

Omics of Male Breast Cancer

Feb 12, 2017 by in ONCOLOGY Comments Off on Omics of Male Breast Cancer

BRCA 1 CD105 BRCA 2 Survivin HER2 gene (HER2/neu or ErbB2) COX-2 MYC Ki67 ER Tropomyosins PR NAT1 BRST2 RAD51B (14q24.1) AR TOX3 (16q12.1) C-erb-2 rs13387042 (2q35) p53 rs10941679 (5p12)…

read more

Metabolomics in Breast Cancer

Feb 12, 2017 by in ONCOLOGY Comments Off on Metabolomics in Breast Cancer

Chemical shift Multiplicity Assignment p-value (pCR vs. SD) p-value (pCR vs. PR) p-value (PR vs. SD) 4.24 m Threonine 0.04 0.28 0.30 1.00 s Isoleucine 0.04 0.01 0.02 2.09 m…

read more

Nutrigenomics in Breast Cancer

Feb 12, 2017 by in ONCOLOGY Comments Off on Nutrigenomics in Breast Cancer

Fig. 6.1 Bioactive food components and its integration with various molecular streams in phenotype progression and development Table 6.1 Factors affecting nutrigenomic research and phenotype Approach Definition and factors Transcriptomics…

read more

Omics Technologies Applied in Breast Cancer Research

Feb 12, 2017 by in ONCOLOGY Comments Off on Omics Technologies Applied in Breast Cancer Research

Fig. 1.1 Relationship between gene, DNA, RNA, and protein (the central dogma of molecular biology) with omics technologies Genomics Genomics may be described as the comprehensive analysis of genes and…

read more

Epigenomics of Breast Cancer

Feb 12, 2017 by in ONCOLOGY Comments Off on Epigenomics of Breast Cancer

Gene (description) Function Sample obtained Case # Methy. status Marker Reference 14-3-3-σ/stratifin (SFN) Cell cycle regulation Cell lines, tissue 20 Hyper Therapeutic Ferguson et al. [202] 14-3-3-σ/stratifin (SFN)å Cell cycle…

read more
Get Clinical Tree app for offline access