Diagnosis and Treatment of Hodgkin’s Lymphoma
Classification Stage I Involvement of a single lymph node region or lymphoid structure (e.g., spleen, thymus, Waldeyer’s ring) or involvement of a single extralymphatic site (IE) Stage II Involvement of…
The Myelodysplastic Syndromes
Fig. 25.1 The incidence of MDS and age. Age adjusted incidence/100,000 individuals. Age in five block years. (Data from Rollison DE, Howlader N, Smith MT et al. Epidemiology of myelodysplastic…
Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia
B lymphoblastic leukemia B lymphoblastic leukemia, not otherwise specified B lymphoblastic leukemia with recurrent genetic abnormalities B lymphoblastic leukemia with t(9;22)(q34;q11.2); BCR-ABL1 B lymphoblastic leukemia with t(v;11q23); MLL rearranged B…
Prevention of Infections in Patients with Hematological Malignancies
Risk factor for infection Risk category Low High General condition including organ function Performance status Good Poor Renal failure No Yes Liver failure No Yes Lung disease No Yes Diabetes…
Supportive Care for Patients with Leukemia: A Historical Perspective
3. Murphy S, Gardner FH. Room temperature storage of platelets. Transfusion. 1976;16:2–3.PubMedCrossRef 4. Hogge DE, Thompson BW, Schiffer CA. Platelet storage for 7 days in second-generation blood bags. Transfusion. 1986;26:131–5.PubMedCrossRef…
Complications and Special Presentations of Plasma Cell Myeloma
•Incidence: 1 % •Associated features –Plasmablastic morphology –Other extramedullary locations –Plasma cell leukemia –Increased lactate dehydrogenase •MRI: diffuse leptomeningeal enhancement (with or without masses) •Median survival: 3 months Modified with…
Therapy-Related Acute Myelogenous Leukemia
Alkylating agent therapy DNA-topoisomerase II inhibitor therapy (epipodophyllotoxins and anthracyclines) Intense therapy High doses of chemotherapy for prolonged periods as in therapy for Hodgkin’s disease and non-Hodgkin’s lymphoma Direct correlation…
Diagnosis and Treatment of Childhood Acute Myeloid Leukemia
Acute myeloid leukemia with recurrent genetic abnormalities AML with t(8;21)(q22;q22); RUNX1-RUNX1T1 (AML1-ETO) [M2] AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 [M4Eo] APL with t(15;17)(q22;q12); PML-RARA [M3] AML with t(9;11)(p22;q23); MLLT3-MLL AML…
Diagnosis and Treatment of Adult Acute Lymphoblastic Leukemia
Complete medical history, including •Past medical history, especially heart, lung, liver or renal disease, and diabetes mellitus (comorbidity score) •Family history •Occupational history Complete physical examination, with special attention to…
Epidemiology and Hereditary Aspects of Acute Leukemia
Fig. 15.1 US acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) incidence rates (age-adjusted, 2000 US standard) by race and sex, diagnosed among residents of nine cancer registry areas…
