Epidemiology of Multiple Myeloma
Fig. 28.1 US myeloma mortality rates (age-adjusted, 2000 U.S. standard) by race and sex, 1953–1957 to 2003–2006 Rates specific for blacks, available since the early 1970s, are higher than rates…
Diagnosis and Treatment of Multiple Myeloma
Disorder Disease definition References Monoclonal gammopathy of undetermined significance (MGUS) All 3 criteria must be met: •Serum monoclonal protein <3 g/dL •Clonal bone marrow plasma cells <10 %, and •Absence…
Cytogenetics of Acute Leukemia
AML with t(8;21)(q22;q22)/RUNX1-RUNX1T1 (AML1-ETO) AML with inv(16)(p13.1q22) or t(16;16)(p13.1q22)/CBFB-MYH11 APL with t(15;17)(q22;q21)/PML-RARA AML with t(9;11)(p22;q23)/MLLT3 -MLL (specify other 11q23/MLL abnormality) AML with t(6;9)(p23;q34)/DEK-NUP214(CAN)a AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)/RPN1-MECOM a AML…
Non-Hodgkin Lymphoma of Childhood
Syndrome Tumor Risk (%) Percent of malignancies that equal NHL Ataxia-telangiectasia Leukemia, NHL, HL, adenocarcinoma >12 41–66 Common variable ID NHL, gastric carcinoma 8–10 45–62 Severe combined ID NHL, HL,…
Platelet and Granulocyte Transfusion
Method Total white blood cells Platelets × 1011 References Mechanical apheresis Cobe spectra V5-LRS <1 × 106 2.56–7.41 [15] Fenwal amicus <1 × 106 2.82–7.14 [15] Cobe V7 turbo <1…
Cytogenetics of Lymphomas
Fig. 44.1 Partial karyotypes of chromosome abnormalities observed in lymphoid malignancies. The abnormal chromosomes are situated on the right side of each pair with the normal homologue on the left….
History of Multiple Myeloma
Fig. 26.1 Plasma cells obtained at the autopsy of Thomas Alexander McBean, January 1846 (wood engravings made from drawings by Mr. Dalrymple) (Reprinted with permission from Dalrymple J. On the…
Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications
Acquired Malignant Nonmalignant Congenital Acute nonlymphoblastic Leukemia Acute lymphoblastic leukemia Chronic myelogenous leukemia Chronic lymphocytic leukemia Non-Hodgkin lymphoma Hodgkin disease Multiple myeloma Myelodysplastic Syndrome Myelofibrosis Agnogenic myeloid metaplasia P. vera…
Viral Infections in Patients with Hematological Malignancies
Herpesviruses Herpes simplex type 1 Herpes simplex type 2 Cytomegalovirus Varicella zoster virus Epstein–Barr virus Human herpesvirus 6 Intestinal viruses Rotavirus Norwalk virus Adenoviruses Astroviruses Coxsackie Caliciviruses Respiratory viruses Respiratory…
Cytogenetic Abnormalities in MGUS and Myeloma
Non-hyperdiploid MM Hyperdiploid MM Translocations Less translocations Younger Older IgA IgG Lambda Kappa Less bone disease More bone disease More aggressive More indolent Females Males Chromosome 13 deleted Chromosome 13…
