Molecular Mechanisms of CML Stem Cell Maintenance
Fig. 2.1 CML stem cell maintenance. CML stem cells self-renew as HSCs do when BCR–ABL kinase activity is inhibited by tyrosine kinase inhibitors (TKIs). Therefore, survival of CML stem cells…
Identification and Biology of CML Stem Cells
Fig. 1.1 Clonal expansion of CML hematopoiesis. A reciprocal translocation between chromosomes 9 and 22 occurs at a hematopoietic stem cell (HSC) stage. This pre-leukemic stem cell expresses BCR-ABL at…
