Multimodality Therapy in Gastric Cancer
Treatment arms Primary end point Secondary end points MAGIC [3] Surgery alone Epirubicin 50 mg/m2 day 1 5-year OS 5-year PFS Cisplatin 60 mg/m2 day 1 HR 0.75 HR 0.66…
The Volume-Outcome Relationship, Standardized Clinical Pathways, and Minimally Invasive Surgery for Esophagectomy
Author ECP patients LOS (PC) (days) LOS (ECP) (days) Mortality (PC) (%) Mortality (ECP) (%) Morbidity (PC) (%) Morbidity (ECP) (%) Zehr et al. (1991–1997) [24] 96 13.6 ± 6.9 9.5 ± 2.8 3.6…
Goals of Surgical Therapy for Esophageal Cancer
Fig. 4.1 (a) The lymphatics of the esophagus are distributed in the form of a submucosal and a paraesophageal plexus that can both drain directly into the periesophageal lymph nodes….
Pathogenesis of Esophageal Cancer
Risk factor Risk Tobacco 4–8× Alcohol 1.3–8× Alcohol dehydrogenase 4× Fruits and vegetables 0.53–0.56× Poverty 8× Gastroesophageal reflux 7.7× Obesity 3.1× Helicobacter pylori infection 0.56–1.1× Squamous Cell Carcinoma Worldwide squamous…
Optimization of Patients for Esophageal Cancer Surgery
Cardiac disease Pulmonary disease Liver disease VTE Nutrition Frailty Risk factors CAD COPD/asthma ETOH Hx of VTE > 10 % Weight loss Age > 65 Prior MI Exercise intolerance Hepatitis Immobility…
