Endoscopic Duodenal–Jejunal Bypass: Endobarrier
Fig. 18.1 Capsule containing the sleeve and the stent positioned over-the-wire to be inserted Besides providing effective weight loss, the Endobarrier™ has proven to be a valid option for diabetes…
Balancing Complications and Metabolic Benefit
Outcome Definition Complete remission Normal measures of glucose metabolism (A1C < 6 %, FBG < 100 mg/dL) for 1 year in the absence of antidiabetic medications. Partial remission Sub-diabetic hyperglycemia (A1C 6–6.4 %, FBG…
Medical Approaches to Weight-Centric Management of Obese Patients with Type 2 Diabetes
Fig. 4.1 Weight loss in Look AHEAD over minimum 8 years of observation. Mean (+SE) weight loss from baseline among participants in the Intensive Lifestyle Intervention (ILI; n = 2570) and Diabetes…
Understanding Diabetes Mellitus: Pathophysiology
Gene Name Function Chromosome Odds ratio PPARG Peroxisome proliferator-activated receptor ϒ Regulates adipocyte differentiation 3 1.19 KCNJ11 Potassium inwardly rectifying channel, subfamily J, member 11 Part of the sulfonylurea receptor…
The History of Metabolic Surgery
Fig. 7.1 The Venus of Willendorf Even a few decades ago, it was still deemed desirable. Townsend et al. [2] nicely documented that “certain ethno-cultural groups associate large body sizes…
Effect of Bariatric Surgery on Incretin Function
Reference Surgery Obese/T2DM Stimulus GLP-1 GIP Sarson et al. [76, 77] RYGBP OB Meal ↓ Halverson et al. [78] RYGBP OB OGTT ↑ Sirinek et al. [79] RYGBP OB OGTT …
Adipocyte Dysfunction, Inflammation, and Insulin Resistance in Obesity
Fig. 5.1 Lean adipose in insulin-sensitive state. The adipocyte is responsive to insulin stimulation, thus prompting glucose uptake via Glut4 transporter, and free fatty acid uptake (FFA). Glucose is converted…
Intragastric Balloon
© Springer Science+Business Media New York 2016Marina Kurian, Bruce M. Wolfe and Sayeed Ikramuddin (eds.)Metabolic Syndrome and Diabetes10.1007/978-1-4939-3220-7_19 19. Intragastric Balloon Nicole Pena Sahdala1 (1) Universidad Pedro Henriquez Urena, Santo Domingo, Dominican Republic Nicole Pena Sahdala Email: nicolepena.md@gmail.com…
Bile Acids, the Microbiome and Metabolic Disease-Implications for Surgery
© Springer Science+Business Media New York 2016Marina Kurian, Bruce M. Wolfe and Sayeed Ikramuddin (eds.)Metabolic Syndrome and Diabetes10.1007/978-1-4939-3220-7_6 6. Bile Acids, the Microbiome and Metabolic Disease-Implications for Surgery Cyrus Jahansouz1 (1) Department of Surgery, University of Minnesota,…
Extending Current Definitions of the Metabolic Syndrome
Components of MS WHO criteria (1999) EGIR (1999) NCEP ATP III criteria (2001) IDF consensus (2005) Obesity/abdominal obesity Body mass index (BMI) ≥30 kg/m2 and/or waist-to-hip ratio >0.90 (M), >0.85…
