43 Antiviral Agents General Principles Raphael Dolin Keywords antiviral; antiviral resistance; correlates of effect; nucleic acid synthesis; protease inhibitors; sensitivity assays; virus load The development of antiviral drugs has historically…
7 Mucosal Immunity Peter B. Ernst Keywords antigen-presenting cell; B cell; cytokine; epithelium; infection; innate lymphoid cell; microbiota; mucosal; network; T cell Mucosal immune responses must discriminate between molecular signals…
4 Innate (General or Nonspecific) Host Defense Mechanisms Carl W. Dieffenbach, Edmund C. Tramont Keywords adaptive immunity; antimicrobial proteins; C-type lectin (CLR)-like receptor family; innate immunity; natural antibodies; NOD-like receptor…
13 Epidemiologic Principles Michael T. Osterholm, Craig W. Hedberg Keywords chain of infection; experimental studies; infectivity; observational studies; odds ratio; pathogenicity; virulence; relative risk; sensitivity; specificity Epidemiologic Study Methods Epidemiology…
10 Human Genetics and Infection Stephen J. Chapman, Adrian V.S. Hill Keywords gene; genome-wide; hemoglobinopathy; HIV; human leukocyte antigen; malaria; mycobacteria; natural selection; polymorphism; Toll-like receptor Genetic variation in the…
2 The Human Microbiome of Local Body Sites and Their Unique Biology Kjersti Aagaard, Ruth Ann Luna, James Versalovic Keywords beneficial microbes; commensalism; dysbiosis; metagenome; microbial ecology; microbiome; microbiota; mutualism;…
1 A Molecular Perspective of Microbial Pathogenicity David A. Relman *, Stanley Falkow Keywords bacteriophage; clonality; commensal; commensalism; diagnostics; ecology; evolution; genomics; horizontal gene transfer; infectious diseases; intracellular parasites; metagenomics;…
