Phenotype Molecular basis Mechanism Consequence AR-addicted Adrenal or intra-tumoral androgen biosynthesis Androgens produced sufficient to activate AR Responds to androgen biosynthesis inhibitors and selected AR antagonists AR mutation Alters ligand…
Fig. 5.1 Schematic of the full-length androgen receptor and exon structure of major splice variants (ARV7 (b) and ARV567 (c)). Domains of AR include the amino (N) terminal domain, the…
Target Agent(s) Phase Summary Identifier mTOR Everolimus (Docetaxel) (Bevacizumab) Ib/II Dose-finding/efficacy study; Docetaxel + everolimus + bevacizumab in metastatic CRPC NCT00574769 mTOR Temsirolimus (Bevacizumab) I/II Dose-finding/efficacy study; Temsirolimus + bevacizumab in metastatic CRPC NCT01083368 mTOR Everolimus…
