Pharmacokinetic Aspects of Regional Tumor Therapy
PK parameter Dimension Relevance t 1/2zp Time Transfer from blood to deep compartment t 1/2el Time Elimination half-life from the body c max Concentration/volume Peak concentration in blood or tissue…
Chemoembolization of Lung Tumors
Model Lung unilateral embolization with DSM ± carboDDP, rats: study of pulmonary microcirculation by measurement of FITC-labeled erythrocytes N 12 (2 × 6) Objective Pulmonary microcirculation Comparisons 1. unilateral embolization with DSM 2. unilateral…
Radiofrequency Ablation for Treating Malignant Tumors to the Liver
Author Method Patients (n) Tumor size (cm) Overall survival p 1 y (%) 3 y (%) 5 y (%) Vivarelli (2004) [17] Surgery 79 n.a. 83 65 n.a. 0.002 RFA…
Liver Metastases of Other Indications
Concept Resection + intra-arterial chemotherapy vs. resection alone N 51 Access Catheter via A. femoralis in truncus coeliacus Therapy d1: 10 mg/m2 mitoxantrone (over 1 h) d2–4: 170 mg/m2 FA (over 10…
Liver Metastases of Neuroendocrine Tumors and CCC
Concept TACE of advanced liver metastases of neuroendocrine tumors (retrospective analysis) N 26 (10× carcinoid syndrome, 2× midgut tumors, 7× pancreatic tumors, 2× malignant insulinomas, 1× stomach carcinoid, 4× CUP)…
CRC Liver Metastases
Concept Adjuvant HAI after resection of colorectal liver metastases (randomized comparison of HAI + IV vs. IV) N 156 Inclusion criteria R0 resection Therapy 1. (HAI + IV): IV: 325 mg/m2 5FU d1–5 (bolus) + 200…
