♦Cytarabine
♦Cytarabine (cye-tar’-a-been) ARA-C, cytosine arabinoside, Cytosar-UR Pregnancy Category D Mechanism of Action Cytarabine is a cell cycle-specific (S phase) antimetabolite that inhibits cell development from the G1 to the S…
♦Cyclophosphamide
♦Cyclophosphamide (cy-klo-foss’-fa-mide) Cytoxan, Neosar Pregnancy Category D Mechanism of Action Cyclophosphamide is a cell cycle-nonspecific nitrogen mustard derivative that acts as an alkylating agent by interfering with DNA replication and…
♦Cladribine
♦Cladribine (kla’-drih-been) Leustatin Pregnancy Category D Mechanism of Action Unclear. A high intracellular concentration of cladribine is believed to inhibit ribonucleotide reductase, causing subsequent DNA strand breaks and inhibition of…
♦Cisplatin
♦Cisplatin (sis’-pla-teen) CDDP, Platinol Pregnancy Category D Mechanism of Action Cisplatin is a widely used heavy metal, cell cycle-nonspecific agent that interferes with cell division by binding to DNA and…
♦Chlorambucil
♦Chlorambucil (klor-am’-byoo-sil) Leukeran Pregnancy Category D Mechanism of Action Chlorambucil is a nitrogen mustard derivative that works as an alkylating agent by interfering with DNA replication and the transcription of…
♦Carmustine
♦Carmustine (car-mus’-teen) BCNU, BICNU Pregnancy Category D Mechanism of Action A cell cycle-nonspecific alkylating agent, carmustine is a ni-trosourea derivative that alkylates DNA by causing cross-links and strand breaks. Indications…
♦Carboplatin
♦Carboplatin (kar’-bo-pla-tin) Paraplatin, CBDCA Pregnancy Category D Mechanism of Action Carboplatin is a cell cycle-nonspecific alkylating agent that prevents cell replication by producing intra- and inter-DNA cross-links. Indications Ovarian cancer…
♦Capecitabine
♦Capecitabine (kap-ah-ceet’-a-bean) Xeloda Pregnancy Category D Mechanism of Action Capecitabine is a prodrug to be activated preferentially at tumor sites, thus improving the therapeutic efficacy of 5-fluorouracil (5-FU). This drug…
♦Bleomycin
♦Bleomycin (blee-oh-mye’-sin) Blenoxane Pregnancy Category D Mechanism of Action A cell cycle-specific antitumor antibiotic that inhibits DNA, RNA, and protein synthesis. Indications Palliative treatment of lymphomas; squamous cell carcinoma of…
