♦Gemcitabine
♦Gemcitabine (gem-see’-ta-bean) Gemzar Pregnancy Category D Mechanism of Action Gemcitabine is a cell cycle-specific (S phase) cytotoxic agent that kills cells in the S phase undergoing DNA synthesis. It also…
♦Flutamide
♦Flutamide (floo’-ta-mide) Eulexin Pregnancy Category D Mechanism of Action This drug is a potent nonsteroidal agent that acts by inhibiting the uptake of androgen or the nuclear binding of androgen…
♦Fluorouracil
♦Fluorouracil (flure-oh-yoor’-a-seel) 5-FU, Adrucil Pregnancy Category D Mechanism of Action Interferes with DNA synthesis and formation of RNA, which are essential for cell division and growth. Causes a thymine deficiency,…
♦Fludarabine Phosphate
♦Fludarabine Phosphate (floo-dar’-a-been) Fludara Pregnancy Category D Mechanism of Action Fludarabine is an antimetabolite that inhibits DNA synthesis by inhibiting ribonucleic reductase, DNA polymerase, and DNA primase. Indications Used in…
♦Floxuridine
♦Floxuridine (flox-yur’-i-deen) FUDR Pregnancy Category D Mechanism of Action Floxuridine is a cytotoxic antimetabolite that acts primarily by interfering with the synthesis of DNA; to a lesser extent, it inhibits…
♦Filgrastim
♦Filgrastim (fill-grass’-tim) Neupogen, G-CSF (granulocyte colony-stimulating factor) Pregnancy Category C Mechanism of Action Increases the number of neutrophils in the bone marrow. Indications ♦ To reduce the incidence of infection…
♦Exemestane
♦Exemestane (ex-e-mes’-tayne) Aromasin Pregnancy Category D Mechanism of Action Exemestane is an irreversible steroidal agent that inactivates aromatase, which converts androgens to estrogens, the primary source of estrogen in postmenopausal…
♦Etoposide Phosphate
♦Etoposide Phosphate (e-to-poe’-side) Etopophos Pregnancy Category D Mechanism of Action Induces DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals. Indications ♦ Refractory testicular…
♦Etoposide
♦Etoposide (e-toe-poe’-side) VePesid, VP-16 Pregnancy Category D Mechanism of Action Etoposide is a cell cycle-specific plant alkaloid that inhibits DNA synthesis in the S and G2 phases so that cells…
♦Estramustine Phosphate Sodium
♦Estramustine Phosphate Sodium (ess-tra-muss’-teen) Emcyt Pregnancy Category D Mechanism of Action The estrogen portion facilitates the selective uptake of the drug into the cells, enhancing the alkylating effect in tissue…
