♦Pipobroman (pip-o-bro’-man) Vercyte Pregnancy Category: Not Available Mechanism of Action Unknown; pipobroman is a polyfunctional cytotoxic alkylating agent that is cell cycle-nonspecific. Indications Polycythemia vera, chronic granulocytic leukemia. Metabolism/Excretion Related…
♦Pentostatin (pen’-toe-stah-tin) Nipent Pregnancy Category D Mechanism of Action An antitumor antibiotic that inhibits the ADA enzyme and causes cell lysis. Indications Alpha-interferon-refractory hairy cell leukemia in adults. Metabolism/Excretion Metabolized…
♦Pegasparagase (peg-ass-par’-a-gase) Oncaspar Pregnancy Category C Mechanism of Action A derivative of the L-asparaginase enzyme, which destroys the amino acid asparagine needed for cancer cell proliferation. Inhibits malignant cell production….
♦Pamidronate Disodium (pam-ee’-dro-nayt) Aredia Pregnancy Category C Mechanism of Action Believed to inhibit bone resorption by blocking the dissolution of calcium phosphate crystals in the bone. Indications Osteolytic bone metastases…
♦Paclitaxel (pass-leh-tax’-el) Taxol Pregnancy Category D Mechanism of Action A novel antimicrotubule cytotoxic agent that promotes mi-crotubule assembly and inhibits the microtubule reorganization that is essential for interphase and mitotic…
♦Muromonab-CD3 (mew-ro’-mon-ab) Orthoclone, OKT3 Pregnancy Category C Mechanism of Action Functions as an immunosuppressant by blocking the function of all T cells. Indications Acute allograft rejection in renal transplant patients;…
♦Mitoxantrone Hydrochloride (mye-toe-zan’-trone) Novantrone Pregnancy Category D Mechanism of Action Cell cycle-nonspecific agent that interacts with DNA and inhibits the DNA enzyme topoisomerase, causing cell lysis. Indications Acute monocytic leukemia,…
♦Mitomycin (mye-toe-mye’-sin) Mutamycin, MTC, Mitomycin-C Pregnancy Category D Mechanism of Action Cell cycle-nonspecific antitumor antibiotic that inhibits DNA, RNA, and protein synthesis, causing cell lysis. Indications Part of combination or…
♦Methotrexate (meth-oh-trex’-ate) MTX, amethopterin Pregnancy Category X Mechanism of Action Cell cycle-specific (S phase) antimetabolite that inhibits folic acid reductase by blocking the enzyme dihydrofolate reductase. Arrests DNA, RNA, and…
