Unit III. Combination Chemotherapy Regimens The use of combination chemotherapy is well established. Combining agents have allowed the clinician to achieve maximum cell kill while trying to minimize toxicity to…
♦Vinorelbine (vin-oh-rel-been’) Navelbine Pregnancy Category D Mechanism of Action An antimitotic agent that inhibits microtubule formation by interfering with nucleic acid synthesis. Indications Non-small cell lung cancer, breast cancer, ovarian…
♦Vindesine (vin’-de-seen) Eldisine, desacetyl vinblastine Pregnancy Category D Mechanism of Action A vinca alkaloid that binds to tubulin and alters the micro-tubular spindle structure, which leads to cell lysis. Indications…
♦Vincristine (vin-kris’-teen) Oncovin, VCR, Vincasar Pregnancy Category D Mechanism of Action A vinca alkaloid that arrests metaphase by binding microtubule protein to the mitotic spindle. Specific for the S phase….
♦Vinblastine (vin-blas’-teen) Velban, VLB Pregnancy Category D Mechanism of Action A cell cycle-specific vinca alkaloid that inhibits mitotic spindle formation by binding to tubulin. Most specific for the M phase….
♦Uracil Mustard (yoor’-a-sill) Pregnancy Category X Mechanism of Action An alkylating agent that binds to DNA, inhibits DNA synthesis, and leads to cell death. Indications Chronic lymphoblastic leukemia, chronic myelogenous…
♦Tretinoin (tret’-i-noyn) Retinoic acid, Vesanoid Pregnancy Category D Mechanism of Action Not understood. This natural retinoid may play a role in hematopoiesis and immune function. Inhibits the proliferation of acute…
♦Topotecan Hydrochloride (toe-poe’-tee-kan) Hycamtin Pregnancy Category D Mechanism of Action A semisynthetic derivative of camptothecin, topotecan inhibits the activity of topoisomerase I, an enzyme necessary for DNA replication. Indications Metastatic…
♦Thioguanine (thye-oh-gwah’-neen) TG, 6-thioguanine, Tabloid Pregnancy Category D Mechanism of Action An antimetabolite that inhibits purine synthesis by substituting for the nucleotide guanine. S phase-specific. Indications Acute lymphocyte leukemia, acute…
