and Steven D. Shapiro2 (1) Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA (2) Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Abstract…
Fig. 6.1 Pathways controlling eicosanoid production. Arachidonic acid is incorporated into membrane glycerophospholipids. Activation of cPLA2 hydrolyzes these lipids to produce free AA. Alternatively, AA can be derived from 2-arachidonylglycrol…
33. Toh B, Wang X, Keeble J, Sim WJ, Khoo K, Wong WC, et al. (2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating…
Model Tumor stage Initiation Promotion Progression/metastasis Adenocarcinoma Pro-inflammatory mediators Transcription factors NFκB, NRF2 NFκB NFκΒ, EGR-1 Cytokines/chemokines TNF, IL4Rα, IL17 IL6, IL17 MCP-1, MIF Eicosanoid pathway cPLA2 EP2 (PGE2) Nuclear…
Potential linkers Source Functions in inflammation Functions in angiogenesis References TNF-α Macrophages Tumor cells Augments E-selectin and VCAM-1 on ECs to promote leukocyte adhesion and inflammation Induces COX-2 Induces IL-8…
Fig. 3.1 Inflammation in lung cancer development. Carcinogens in tobacco smoke induce inflammatory damage directly on normal epithelium. Additionally, exposure to tobacco smoke leads to induction and recruitment of proinflammatory…
© Springer Science+Business Media New York 2015Steven M. Dubinett (ed.)Inflammation and Lung Cancer10.1007/978-1-4939-2724-1_7 7. Inflammation and Lung Cancer: Addressing Inflammation with Immunotherapy Sherven Sharma1 , Siwen Hu-Lieskovan2 , Steven M. Dubinett3 and Jay Moon Lee4 (1) Division of Pulmonary and…
