Fig. 1.1 Nature of febrile episodes in neutropenic patients 1.4 Microbiologically Documented Infections Microbiologically documented infections also account for 25–30 % of febrile episodes in neutropenic patients (Fig. 1.1). The…
Granulocyte count <500/μl or <1,000/μl with predicted decline to ≤500/μl Single oral temperature of >38.3 °C or ≥38.0 °C × 2 within 12 h or ≥38.0 °C over ≥1 h No obvious…
Microorganism Management Coagulase-negative staphylococci Catheter can be removed or retained If removed, systemic antibiotics should be administered for 5–7 days If catheter is retained, treat with a systemic antibiotic and…
Duration <1 week: moderate risk >1 week: high risk Absolute neutrophil count (ANC) <1,000/μL: moderate risk <100/μL: high risk However, the term neutropenia is frequently used in clinical practice as…
Bacterial pathogens Streptococcus pneumoniae Haemophilus influenzae Neisseria meningitidis Nocardia species Salmonella species Listeria monocytogenes Campylobacter species Legionella species Capnocytophaga species Mycobacteria Fungal pathogens Aspergillus species Zygomycetes (Mucorales) Fusarium species Scedosporium…
L. monocytogenes a S. pneumoniae Staphylococcus spp. Pseudomonas spp. Gram-negative aerobic bacilli N. meningitidis Candida spp. b Aspergillus spp. Cryptococcus neoformans b Varicella zoster virusc Herpes simplex virusc Cytomegalovirus P….
Type of prophylaxis and clinical condition Recommendation and gradinga Antibacterial prophylaxis Patients with acute leukemia and adult SCT recipients after myeloablative therapy A fluoroquinolone with systemic activity including P. aeruginosa…
Fig. 5.1 Frequency of single-agent bacteremia in IATC-EORTC trials Since the turn of the twenty-first century, the reports emerged indicating that GNB have gained importance again but this time with…
