Antibacterial Agents

Sep 20, 2016 by in HEMATOLOGY Comments Off on Antibacterial Agents

Dosing regimen Duration of infusion (h) MIC (μg/mL) Probability of patients achieving a target T > MIC of 30 % 35 % 40 % 45 % 500 mg every 8…

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Central Nervous System Infections

Sep 20, 2016 by in HEMATOLOGY Comments Off on Central Nervous System Infections

Fig. 13.1 Algorithm to diagnose and to treat empirically/preemptively CNS infections in hematology patients Lumbar puncture and cerebrospinal fluid (CSF) analysis should follow the algorithm in Fig. 13.1 and are…

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Myeloid Growth Factors

Sep 20, 2016 by in HEMATOLOGY Comments Off on Myeloid Growth Factors

Tumor FN-Risk (%) Regimen Breast cancer >20 AC docetaxel, doxorubicin/docetaxel, doxorubicin/paclitaxel, TAC 10–20 AC, EC, docetaxel, FE120C (q4 weeks), CEF <10 CMF Colon cancer 10–20 5-FU/folinic acid FOLFIRI (5-FU/folinic acid/irinotecan)…

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Pulmonary Complications

Sep 20, 2016 by in HEMATOLOGY Comments Off on Pulmonary Complications

Fig. 10.1 Diagnostic procedures and treatment of neutropenic patients with fever and suspected or proven lung infiltrates. CT computed tomography, BAL bronchoalveolar lavage. Dotted lines indicate exceptions from recommended procedure…

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Gastrointestinal Complications

Sep 20, 2016 by in HEMATOLOGY Comments Off on Gastrointestinal Complications

  Early onset <28 days Management GI mucositis Chemotherapy/irradiation complicated by OVS or CoNS bacteraemia Pain killers (morphine) and antibiotics Oesophagitis Chemotherapy Antacids Herpes simplex Antiviral prophylaxis Candida spp. Antifungal…

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Antifungal Agents

Sep 20, 2016 by in HEMATOLOGY Comments Off on Antifungal Agents

Fig. 15.1 Targets of systemic antifungal agents Clinical outcomes in susceptible isolates are best predicted by the peak serum level to MIC ratio. Serum drug levels are infrequently measured and…

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