Fig. 7.1 Contract-enhanced CT demonstrates vessel erosion in a consolidating infiltrate of the left lung. An apposition thrombus can be depicted in the pulmonary artery of the left lower lobe…
Dosing regimen Duration of infusion (h) MIC (μg/mL) Probability of patients achieving a target T > MIC of 30 % 35 % 40 % 45 % 500 mg every 8…
Fig. 13.1 Algorithm to diagnose and to treat empirically/preemptively CNS infections in hematology patients Lumbar puncture and cerebrospinal fluid (CSF) analysis should follow the algorithm in Fig. 13.1 and are…
Tumor FN-Risk (%) Regimen Breast cancer >20 AC docetaxel, doxorubicin/docetaxel, doxorubicin/paclitaxel, TAC 10–20 AC, EC, docetaxel, FE120C (q4 weeks), CEF <10 CMF Colon cancer 10–20 5-FU/folinic acid FOLFIRI (5-FU/folinic acid/irinotecan)…
Fig. 10.1 Diagnostic procedures and treatment of neutropenic patients with fever and suspected or proven lung infiltrates. CT computed tomography, BAL bronchoalveolar lavage. Dotted lines indicate exceptions from recommended procedure…
Patient-related factors Advanced age (≥65 years) increases risk [26, 28, 108] Performance status ECOG ≥2 increases risk [66, 109] Nutritional status Low serum albumin <35 g/l is associated with increased…
Hypotension (defined as systolic blood pressure <90 mmHg or the need for pressor support to maintain blood pressure) Respiratory failure (defined as arterial oxygen pressure less than 60 mmHg while…
Early onset <28 days Management GI mucositis Chemotherapy/irradiation complicated by OVS or CoNS bacteraemia Pain killers (morphine) and antibiotics Oesophagitis Chemotherapy Antacids Herpes simplex Antiviral prophylaxis Candida spp. Antifungal…
Microorganism Management Coagulase-negative staphylococci Catheter can be removed or retained If removed, systemic antibiotics should be administered for 5–7 days If catheter is retained, treat with a systemic antibiotic and…
Fig. 1.1 Nature of febrile episodes in neutropenic patients 1.4 Microbiologically Documented Infections Microbiologically documented infections also account for 25–30 % of febrile episodes in neutropenic patients (Fig. 1.1). The…
