Fig. 7.1 The JAK-STAT signalling pathway. Upon binding to the membrane receptors, cytokines initiate downstream signalling cascades through the JAK-STAT pathway. Cytokine receptor homodimers or heterodimers phosphorylate and activate JAKs,…
Fig. 8.1 DNA mismatch errors commonly occur at unstable genomic regions with multisatellite repeats. The repair of such DNA mismatch errors is the function of the MMR system. This process…
Fig. 3.1 Cancer vaccination and induction of T cell activation Vaccine Platforms and Vectors Common Mechanisms of Action This section will discuss various therapeutic cancer vaccine constructs, including peptide, DNA,…
Phase Regimen Patient population Results I Pembrolizumab (anti-PD-1 antibody) Advanced solid tumours, including oesophageal cancer ORR: 30.4 % (29.4 % in squamous cell carcinoma vs. 40 % in adenocarcinoma); 12-month…
