Summary of Key Points • Distinct cellular phenotypes are based on differential gene expression, which is achieved through heritable epigenetic modifications that maintain active and inactive chromosomal regions. • Epigenetic…
Summary of Key Points • The use of mouse models to study the initiation and evolution of lung cancers has been crucial in advancing the field through the identification of…
Summary of Key Points • Cancer genomes are characterized by the presence of a variety of alterations including base substitutions, copy-number alterations (amplifications or deletions), and structural rearrangements (translocations or…
Summary of Key Points • Lung cancers commonly have structural chromosome aberrations and aneuploidy, with many of them associated with carcinogenesis. • Gene amplification is a common mechanism of oncogenic…
Summary of Key Points • This chapter provides a review of some of the most promising recent studies of diagnostic biomarkers in lung cancer. • We discuss the challenges and…
Summary of Key Points • Lung cancer incidence and mortality has declined among men in many countries, following a decline in the prevalence and level of smoking. Among women, lung…
Summary of Key Points • Most chemoprevention research is focused on natural products and is not amenable to traditional pharmaceutical development. • Robust research and development for lung cancer chemoprevention…
Summary of Key Points • Epidemiology of lung cancer is still changing: in the last 10 years lung cancer became the first cause of cancer-related deaths in both men and…
Summary of Key Points • Smoking is the predominant risk factor for development of lung cancer. As tobacco is introduced to societies, common patterns emerge. Typically, it is first used…
Summary of Key Points • The National Lung Screening Trial has definitively shown a reduction in lung cancer mortality in a research setting but effective implementation of a lung cancer…
