© Springer International Publishing Switzerland 2017Wojciech Golusiński, C. René Leemans and Andreas Dietz (eds.)HPV Infection in Head and Neck CancerRecent Results in Cancer Research20610.1007/978-3-319-43580-0_20 Update on De-intensification and Intensification Studies in HPV Hisham Mehanna1, 2 (1)…
Fig. 1 Phylogenetic tree of the HPV16 variants identified by Yamada et al. (1995) in the United States within a sample of 30 HPV16 isolates based on parsimony analysis. Combined sequences…
© Springer International Publishing Switzerland 2017Wojciech Golusiński, C. René Leemans and Andreas Dietz (eds.)HPV Infection in Head and Neck CancerRecent Results in Cancer Research20610.1007/978-3-319-43580-0_19 Cancer Immunology and HPV Barbara Wollenberg1 (1) Department of Otorhinolaryngology, University of…
© Springer International Publishing Switzerland 2017Wojciech Golusiński, C. René Leemans and Andreas Dietz (eds.)HPV Infection in Head and Neck CancerRecent Results in Cancer Research20610.1007/978-3-319-43580-0_18 Predictive Factors for Outcome and Quality of Life in HPV-Positive and…
© Springer International Publishing Switzerland 2017Wojciech Golusiński, C. René Leemans and Andreas Dietz (eds.)HPV Infection in Head and Neck CancerRecent Results in Cancer Research20610.1007/978-3-319-43580-0_13 Should We De-escalate the Treatment for HPV-Positive Tumors? Andreas Dietz1, 2 , Gunnar Wichmann1,…
Fig. 1 NTCP values (risk on side effects) according to the 6 different approaches. CRT-70 current standard chemoradiation; BioRT-70 standard radiotherapy with cetuximab; CRT-56 reduced radiation dose chemoradiation; CPT-70 standard radiation…
Study Method Tested Positive (%) Citation SPECTRUM P16 443 99 (22 %) Vermorken et al., Lancet Oncol (2013) EXTREME P16 381 41 (12 %) Vermorken et al., Ann Oncol (2014) EXTREME HPV…
Authors Year No.pts Subsite % HPV Treatment HR Gillison et al. 2000 252 H&N 25 Surg a/o RT 0.40 Licitra et al. 2006 90 OPC 19 Surg ± RT 0.26 Fakhry et…
Fig. 1 HPV-attributable fractions for head and neck cancers according to positivity and/or over-expression of selected biomarkers of HPV-induced carcinogenesis Figure 2 shows oropharyngeal HPV-AFs by geography, gender, age group, and year of…
Reference Lesion No. of cases Method HPV-positivity Types detected Syrjänen et al. (1983a, b, c, d) SCC 40 ICH 8/40 20 % Syrjänen et al. (1983a, b, c, d) SCC 1…
