Differential Diagnosis of the Bleeding Patient
Differential Diagnosis of the Bleeding Patient Jill M. Johnsen Barbara A. Konkle The hematologist is often faced with the question of whether a patient has an underlying bleeding disorder. This…
Overview of Inherited Hemorrhagic Disorders
Overview of Inherited Hemorrhagic Disorders Gilbert C. White II Harold R. Roberts Victor J. Marder The focus in Section A of Part III of this book is on inherited hemorrhagic…
Laboratory Markers of Endothelial Cell Activation and Dysfunction
Laboratory Markers of Endothelial Cell Activation and Dysfunction Eduard Shantsila Gregory Y.H. Lip Robert P. Hebbel The diverse functions of the vascular endothelium are of critical importance in maintaining physiologic…
Leukocyte Function and Contribution to Disease
Leukocyte Function and Contribution to Disease Edith Van De Vijver Taco W. Kuijpers Inflammation is a tightly regulated process initiated after tissue injury or infection. The main function of inflammation…
Endothelial Cell-Blood Cell Interactions
Endothelial Cell-Blood Cell Interactions Klaus Ley Interactions between monocytes, platelets, and endothelial cells are intimately involved with and are of key importance for the regulation of hemostasis, thrombosis, inflammation, and…
Heparin and Vascular Proteoglycans
Heparin and Vascular Proteoglycans Douglas M. Tollefsen Lijuan Zhang Heparin is a sulfated glycosaminoglycan isolated from mammalian tissues that are rich in mast cells. When administered intravenously, heparin binds to…
Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway
Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway Wolfram Ruf Tissue and vascular injury requires a rapid hemostatic response that is critically dependent on the tissue factor (TF)-initiated extrinsic coagulation pathway….
Role of the Endothelium in Hemostasis
Role of the Endothelium in Hemostasis Michael J. Krisinger Edward M. Conway Hemostasis and coagulation, which refer to the arrest of bleeding and the formation of a fibrin clot, respectively,…
Endothelial Cell Function
Endothelial Cell Function William C. Aird The endothelium is an expansive organ, reaching all recesses of the human body. At one time, it was believed that endothelial cells (ECs) were…
Blood Vessel Wall in Health and Disease
Blood Vessel Wall in Health and Disease Keith R. Brunt Sonya Hui Jagdish Butany Mansoor Husain Large arteries and veins are comprised of concentric layers of smooth muscle cells (SMCs)…
