Transplants in Myelodysplastic Syndromes
Myelodysplastic syndromes are one of the most common hematological disorders in the elderly. Therefore, an increase in the prevalence of de novo but also of secondary forms after prior chemotherapy…
Allogeneic Hematopoietic Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia
This review discusses the use of prognostic factors, patient and donor selection, choice of conditioning regimens, and timing of transplant. It also describes the management of Philadelphia-positive acute lymphocytic leukemia…
Transplantation in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is associated with poor outcome mainly because of relapse. The best antileukemic treatment is allogeneic stem cell transplantation. However, the associated significant nonrelapse mortality limits both…
Bone Marrow Transplantation
Bipin N. Savani, MD, Editor Mohamad Mohty, MD, PhD, Editor Since the first 3 cases of successful allogeneic hematopoietic stem cell transplantation (HSCT) in 1968, the number of HSCTs performed…
Referral to Transplant Center for Hematopoietic Cell Transplantation
Hematopoietic cell transplantation is a complex and highly specialized medical procedure offered by selected centers with the requisite expertise and resources. Timely referral to a transplant center is among the…
Hematopoietic Stem Cell Transplantation for Primary Immunodeficiencies
Allogeneic hematopoietic stem cell transplantation has been shown to be curative for well-described as well as newly discovered immunodeficiencies. However, it is difficulty to define a universal transplant regimen given…
Bone Marrow Transplantation for Acquired Severe Aplastic Anemia
This article addresses current transplant options for patients with acquired severe aplastic anemia (SAA). This discussion includes ongoing progress in the use of SAA in the setting of unrelated donor…
Allogeneic Stem Cell Transplantation for Thalassemia Major
Allogeneic stem cell transplant remains the only curative option for β-thalassemia major. In patients with good risk features it is reasonable to anticipate a greater than 90% chance of a…
Hematopoietic Stem Cell Transplantation for Patients with Sickle Cell Disease
Research has solidified matched sibling marrow, cord blood, or mobilized peripheral blood as the best source for allogeneic hematopoietic stem cell transplantation for patients with sickle cell disease, with low…
High Dose Melphalan and Autologous Peripheral Blood Stem Cell Transplantation in AL Amyloidosis
AL amyloidosis is the most common form of systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. It is often difficult to recognize because of its many manifestations….
