Combinatorial Approach to Treatment of Melanoma

Mar 1, 2017 by in HEMATOLOGY Comments Off on Combinatorial Approach to Treatment of Melanoma

There are multiple effective and well-tolerated systemic therapy treatments for the treatment of advanced melanoma, as well as new immunotherapy and targeted therapy agents in clinical trials. Traditional cytotoxic chemotherapy…

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Interferon, Interleukin-2, and Other Cytokines

Mar 1, 2017 by in HEMATOLOGY Comments Off on Interferon, Interleukin-2, and Other Cytokines

Cytokines are a diverse group of signaling molecules with immunomodulatory activity. This article reviews the application of cytokine therapy in melanoma with a focus on interferon-α and interleukin-2. In addition,…

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Immune Checkpoint Blockade

Mar 1, 2017 by in HEMATOLOGY Comments Off on Immune Checkpoint Blockade

Since the development and approval of Ipilimumab, the first immune checkpoint inhibitor licensed for the treatment of metastatic melanoma, clinicians have gained a better understanding of the mode of action,…

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Vaccines and Melanoma

Mar 1, 2017 by in HEMATOLOGY Comments Off on Vaccines and Melanoma

The potential for therapeutic efficacy of a melanoma vaccine has been evident preclinically for many years. In melanoma patients, vaccines have resulted in the induction of immune responses, although clinical…

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Treatments for Noncutaneous Melanoma

Mar 1, 2017 by in HEMATOLOGY Comments Off on Treatments for Noncutaneous Melanoma

Historically the approach to treating noncutaneous melanoma was largely guided by the experience with cutaneous melanoma, particularly in the metastatic setting. However, as genetic tools have allowed clinicians to better…

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Targeted Therapies for Cutaneous Melanoma

Mar 1, 2017 by in HEMATOLOGY Comments Off on Targeted Therapies for Cutaneous Melanoma

Melanoma is resistant to cytotoxic therapy, and treatment options for advanced disease have been limited historically. However, improved understanding of melanoma driver mutations, particularly those involving the mitogen-activated protein kinase…

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Melanoma Adjuvant Therapy

Mar 1, 2017 by in HEMATOLOGY Comments Off on Melanoma Adjuvant Therapy

Adjuvant therapy targets melanoma micrometastases in patients with surgically resected disease that carry a high risk of death from melanoma recurrence. In this setting, adjuvant therapy provides the greatest opportunity…

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