Targeting the Insulin Growth Factor Receptor 1
The IGF axis is a tightly controlled endocrine system that regulates cell growth and development, known to have an important function in cancer biology. IGF1 and IGF2 can promote cancer…
mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase. It is ubiquitously expressed in cells and is a therapeutic target for the cancer treatment arsenal. Despite the great responses…
Therapeutic Antibodies Against Cancer
Antibody-based therapeutics against cancer are highly successful and currently enjoy unprecedented recognition of their potential; 13 monoclonal antibodies (mAbs) have been approved for clinical use in the European Union and…
Clinical Drug Development in 2012
Franco Muggia, MD, Guest Editor Hosting as editor this 2012 issue of Hematology Oncology Clinics of North America is an opportunity to reflect on trends in clinical drug development. In…
