Imaging Studies for Germ Cell Tumors
Imaging plays an important role in the management of patients with testicular germ cell tumors. This article reviews the role of imaging in the diagnosis, staging, and posttreatment restaging of…
Etiologic Differences Between Seminoma and Nonseminoma of the Testis: A Systematic Review of Epidemiologic Studies
Descriptive epidemiologic features of testicular cancer suggest that the etiologies of seminoma and nonseminoma of the testis differ. To address this, the authors conducted a systematic review of 150 case-control…
Biology of Germ Cell Tumors
Testicular cancer has been a model for a curable malignancy. The existence of an array of potential new therapies is the result of a prodigious effort in the researching and…
Late Relapse of Germ Cell Tumors
This article highlights relevant aspects of the rare late relapses of malignant germ cell tumors (MGCTs), which by definition occur at least 2 years after successful treatment. In most reports,…
Testicular Cancer Survivorship
Because of a rising incidence of, and declining mortality from, testicular cancer, there are an increasing number of survivors of testicular cancer. Given their young age at diagnosis, the survivors…
Treatment of Brain Metastases from Germ Cell Tumors
Brain metastases occur in approximately 10% of patients with advanced metastatic germ cell tumors. Patients with nonseminomatous histology, lung metastases, and high β-human chorionic gonadotropin levels are at higher risk…
Role of Postchemotherapy Retroperitoneal Lymph Node Dissection in Advanced Germ Cell Tumors
Advanced germ cell tumors (GCTs) are curable with the appropriate integration of cisplatin-based chemotherapy and postchemotherapy surgical resection of residual masses. For men with retroperitoneal metastases, postchemotherapy retroperitoneal lymph node…
Third-Line Chemotherapy and Novel Agents for Metastatic Germ Cell Tumors
Although germ cell tumors (GCT) are among the most curable solid tumors, a subset of patients with GCT experience relapse or progression despite appropriate cisplatin-based therapy or first-line salvage therapy….
Stage II Seminomas and Nonseminomas
Although a rare presentation for testicular germ cell tumors, the optimal management for stage II disease generates considerable debate, which is, in large part, because of the potential curative role…
A Review of Second-line Chemotherapy and Prognostic Models for Disseminated Germ Cell Tumors
Despite an excellent prognosis even for patients with disseminated disease, about 20% to 30% of men with advanced germ cell tumors are refractory to first-line chemotherapy or experience disease recurrence…
