Chemotherapy Dose Late effect Baseline screening Anthracycline ≥300 mg/m2 or Cardiomyopathy valvular, pericardial damage, coronary artery disease EKG, ECHO (Doxorubicin >200 mg/m2 + Daunorubicin Chest XRT ≥30 Gy Epirubicin HD…
Study GWAS vs. candidate gene Study design Replication Sample size Results Therapy-related leukemia-associated with exposure to alkylating agents and topoisomerase II inhibitors Genome-wide association studies Knight et al. 2009 [90]…
Question Response Did the patient have any of the following tumor types: neuroblastoma, brain tumor, germ cell tumor, osteosarcoma, hepatoblastoma? □ Yes □ No Did the patient receive cisplatin chemotherapy?…
Cancer treatment risk factor Potential late effect Additional risk factors Recommended evaluation Evidence scorea Mercaptopurine Thioguanine Veno-occlusive disease (VOD) Viral hepatitis Screening 2A Prior VOD Siderosis Mercaptopurine Thioguanine Methotrexate Hepatic…
Stage N Treatment 6-Year EFS% 6-Year survival 1 41 S + BEP 95 95.1 2 16 S + BEP 87.5 93.8 3 58 S + HDP/EB vs. BEP 96.6 97.3 4 16 S + HDP/EB vs. BEP 86.7…
Fig. 8.1 Mechanisms of pulmonary dysfunction and/or growth by hematopoietic stem cell transplantation (HSCT). BO bronchiolitis obliterans, BOOP bronchiolitis obliterans organizing pneumonia, DAH diffuse alveolar hemorrhage, IPS idiopathic pneumonia syndroma…
Disease Treatment Potential CNS late effects Craniopharyngioma Surgical resection/biopsy, cyst fenestration, radiation therapy Panhypopituitarism, obesity, hypogonadism, lower physical health and psychosocial difficulties Optic Pathway Glioma Chemotherapy (Carboplatin, Vincristine, CCNU, 6-thioguanine,…
Function Complication Therapy-related risks Relationship to time, dose to gland or organ when applicable Linear Growth GH deficiency Surgery Damage to the pituitary by tumor expansion and/or surgery Radiotherapy to…
© Springer New York 2015Grace A. Mucci and Lilibeth R. Torno (eds.)Handbook of Long Term Care of The Childhood Cancer SurvivorSpecialty Topics in Pediatric Neuropsychology10.1007/978-1-4899-7584-3_3 3. The European Experience of Establishing Guidelines for Surveillance of…
© Springer New York 2015Grace A. Mucci and Lilibeth R. Torno (eds.)Handbook of Long Term Care of The Childhood Cancer SurvivorSpecialty Topics in Pediatric Neuropsychology10.1007/978-1-4899-7584-3_2 2. Developmental Considerations in the Transition from Child and Adolescent…
