Keywords Dendritic cell vaccination, Major histocompatibility complex (MHC), CD11c + myeloid and CD11c − plasmacytoid dendritic cells, Clinical trials, Transfection, Viral transduction, Tumor cell hybrids, Pathogen-associated molecular patterns (PAMP), MHC…
Keywords Cancer gene therapy, molecular imaging, systemic gene delivery, tumor targeting, vascular targeting, bacteriophage, adeno-associated virus Introduction Gene therapy has attracted considerable attention in the past few decades. One…
Keywords Oncolytic virus, molecular imaging, bioluminescence imaging, fluorescence imaging, PET, SPECT Preclinical Imaging of Viral Gene Expression One important reason for the ongoing and increasing success of oncolytic viruses…
Keywords Gene therapy, clinical trial, FDA, somatic cells Introduction Once a clinical gene therapy target has been identified, it is a lengthy process between proof-of-concept studies and implementation of…
Keywords Lentiviral vector, lentivector, cancer vaccine, gene therapy, immunotherapy, cancer Introduction The immune system likely evolved to fight off disease caused by infections with foreign pathogens. However, it has…
Keywords RNA interference (RNAi), short hairpin RNA (shRNA), ABCD nanoparticle, convection-enhanced delivery (CED), O 6 -methylguanine–DNA methyltransferase (MGMT), malignant glioma, temozolomide (TMZ), genetically modified T cell therapy Introduction Gene…
Keywords Tumor microenvironment, poxvirus, immunotherapy, immune escape Introduction The underlying hypothesis/strategy of our approach to immunotherapy is that by modulating the tumor microenvironment, we will be able to induce…
Keywords Cancer clinical trials, DNA, plasmid, vaccine Introduction Vaccination ranks among mankind’s greatest medical achievements. Routine immunization has eradicated small pox; virtually stamped out polio; and reduced the worldwide…
Keywords T cell receptor, chimeric antigen receptor, cancer, adoptive immunotherapy, gene therapy Introduction There are two types of immune responses: humoral immunity and cellular immunity. Humoral immunity is mediated…
Keywords Chemokines, antitumor immunity, immunotherapy, dendritic cells, tumor-infiltrating T cells Introduction Dendritic cells (DCs) are highly specialized, professional antigen-presenting cells (APCs) that activate naive T cells and are being…
