Targeted Systemic Delivery of Therapeutic siRNA
Keywords siRNA, RNAi, cancer, targeted delivery, theranostics Introduction RNA interference (RNAi) is a relatively new and highly promising technology for gene therapy ( Figure 4.1 ). RNAi is a…
Selectively Replicating Oncolytic Adenoviruses Combined with Chemotherapy, Radiotherapy, or Molecular Targeted Therapy for Treatment of Human Cancers
Keywords Oncolytic virus, adenovirus, chemotherapy, radiotherapy, molecular targeted therapy, clinical trial, combined therapy Introduction Gene and vector-based molecular therapies for cancer encompass a wide range of treatment types that…
Modified Oncolytic Herpesviruses for Gene Therapy of Cancer
Keywords Herpes simplex virus, immunotherapy, oncolysis, advanced cancer, vaccine Introduction Recent advances in viral genome sequencing and elucidation of viral protein function combined with a better understanding of tumor…
Gene Therapy in Radiotherapy of Cancer
Keywords Radiotherapy, Radioprotection, MnSOD-PL Introduction: The Radiotherapy Update Radiation therapy (radiotherapy) remains one of the three critical approaches toward the management of the cancer patient, along with surgery and…
Advances in Oncolytic Virotherapy for Brain Tumors
Keywords Oncolytic virotherapy, brain tumors, gliomas, adenoviruses, autophagy, therapy, cancer Introduction Oncolytic virotherapy utilizes the ability of replicating viruses to selectively infect malignant cells, replicate within them, and subsequently…
Electroporation Gene Therapy
Keywords Electroporation, gene therapy, cancer, nucleic acids, vaccine Introduction Electroporation or electropermeabilization (EP) is a physical method of introducing polar molecules such as DNA into eukaryotic cells through the…
Gene-Directed Enzyme Prodrug Cancer Therapy
Keywords Suicide gene, GDEPT, cancer therapy, enzyme prodrug, thymidine kinase, nitroreductase, cytosine deaminase, carboxypeptidase G2, cytochrome P450, bystander effect Introduction Cancer chemotherapy has had an evolutionary history since the…
Bacterial Delivery of RNAi Effectors
Keywords Transkingdom RNAi (tkRNAi), bacteria-mediated RNAi (bmRNAi), RNA-based therapeutics, RNA interference (RNAi), Cancer, Bacteria Introduction During approximately the past three decades, researchers have been searching for new and improved…
Viral Insertion Site Detection and Analysis in Cancer Gene Therapy
Keywords Viral insertion sites, gene therapy, insertional mutagenesis, lentivial vectors, retroviral vectors, provirus, P140K MGMT Introduction: Why we Should Know Viral Insertion Sites Cancer gene therapy is an emerging…
Targeting Tumor Vasculature Using Adeno-Associated Virus Phage Vectors Coding Tumor Necrosis Factor-α
Keywords Targeted anti-angiogenic gene therapy, nonviral vector, viral vector, tumor-specific promoter, antibody conjugation, peptide conjugation, adeno-associated virus phage, tumor necrosis factor-α Introduction The microenvironment in which a tumor originates…
