Oncohema Key

TABLE 2 | Methylation implicated in malignant transformation of monoclonal gammopathy of uncertain significance (MGUS) to Multiple Myeloma (MM) P16 (CDKN2A) P16 is an inhibitor of cyclin-dependent kinases (CDKs) and…

Figure 20.1.1 Overview of McrBC-based fractionation (Lippman et al., 2005; Ordway et al., 2006) coupled with CHARM analysis (Irizarry et al., 2008). Genomic DNA is sheared to 1.5 to 3.0…

Figure 10.6.1 Flow chart for methylation detection using bisulfite treatment and PCR. Bisulfite treatment converts unmethylated Cs to Us. Because PCR amplification then proceeds using a primer containing complementary As…

FIGURE 1 | Cell type specificity of DNA methylation. This figure shows the dissimilarity of cell types based on their methylation frequencies from targeted bisulfite data that covered CpG islands…

Figure 21.22.1 MAPit overview for mapping m5CG and chromatin accessibility in mammalian nuclei. Nuclei are isolated from cultured cells of interest grown under desired experimental conditions. Isolated nuclei are then…

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FIGURE 1 | The INK4-ARF signaling network. Physiologic mitogenic signals (green light, top left) stimulate the transcription of genes encoding D-type cyclins and facilitate their assembly into stable complexes with…