Resistance to Thyroid Hormone

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Resistance to Thyroid Hormone

FIGURE 94-1. Transport, deiodination, and nuclear action of thyroid hormones. Transporters are required for passage of T3 and T4 across the plasma membrane, facilitating hormone uptake, efflux, or both. Deiodinases…

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Chronic (Hashimoto’s) Thyroiditis

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Chronic (Hashimoto’s) Thyroiditis

This chapter focuses on Hashimoto’s thyroiditis, also known as chronic lymphocytic thyroiditis, chronic autoimmune thyroiditis, and lymphadenoid goiter. In the early stage, patients are euthyroid and have no or a…

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Adrenocorticotropic Hormone

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Adrenocorticotropic Hormone

FIGURE 10-1. Schematic representation of the hypothalamic-pituitary-adrenal axis, showing sites of glucocorticoid negative feedback. ACTH, Adrenocorticotropic hormone; CRH, corticotropin-releasing hormone. History The many important contributions made to the understanding of…

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Ketoacidosis and Hyperosmolar Coma

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Ketoacidosis and Hyperosmolar Coma

FIGURE 46-1. Feedback control of ketosis during an extended fast. Ketogenesis is activated by a rise in the molar ratio of glucagon to insulin, which induces lipolysis in adipose tissue…

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Disorders of Calcification: Osteomalacia and Rickets

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Disorders of Calcification: Osteomalacia and Rickets

FIGURE 70-1. Undecalcified sections of a bone biopsy from a patient with an adult-onset renal phosphate leak. A, Unstained. B, Microradiograph. C, Ultraviolet photomicrograph demonstrating fluorescence (F) of tetracycline administered…

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Hypoglycemia and Hypoglycemic Syndromes

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Hypoglycemia and Hypoglycemic Syndromes

FIGURE 47-1. Hypoglycemia—Major barrier to intensive diabetes management. (Data from Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977–986.) Death from hypoglycemia can be considered on the…

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Iodine Deficiency Disorders

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Iodine Deficiency Disorders

Iodine deficiency remains a public health problem in 47 countries (Fig. 88-1). However, progress has been made since 2003; 12 countries have progressed to optimum iodine status, and the percentage…

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