Obesity: The Problem and Its Management
Using the definitions in Table 28-1, the prevalence of obesity in U.S. adults doubled between 1980 and 2002.8 Findings from the most recent National Health and Nutrition Examination Survey (NHANES…
Hereditary Disorders of the Skeleton
FIGURE 67-1. Osteopetrosis. This teenage girl with Albers-Schönberg disease has a “rugger-jersey” spine typical of adult (“benign”) osteopetrosis. The vertebral end plates are markedly thickened. Skeletal scintigraphy reveals fractures and…
Lipoprotein Metabolism and the Treatment of Lipid Disorders
FIGURE 42-1. The upper panel of the figure lists the density range that encompasses each lipoprotein class and the major tissue in which the lipoprotein is synthesized. The bottom panel…
Endocrinology: Impact on Science and Medicine
FIGURE 1-1. Timeline of selected advances in endocrinology. (ATDs, Antithyroid drugs; CAH, congenital adrenal hyperplasia; DA, dopamine; I-, iodine; OCPs, oral contraceptive pills; Pheo, pheocromocytoma; RAI, radioactive iodine; Rx, treatment;…
Paget’s Disease of Bone
FIGURE 71-1. Radiograph demonstrating osteoporosis circumscripta of the skull affecting the frontal and temporal regions. FIGURE 71-2. Radiograph of an osteolytic lesion of Paget’s disease that began in the diaphysis…
Development of the Endocrine Pancreas
FIGURE 31-1. Schematic outline of the development of the mammalian pancreas. 1, Dorsal and ventral buds arise from the duodenal part of the primitive gut endoderm (blackened). 2, The dominant…
Androgen Physiology, Pharmacology, and Abuse
FIGURE 137-1. Pathways of testosterone biosynthesis and action. In men, testosterone biosynthesis occurs almost exclusively in mature Leydig cells by the enzymatic sequences illustrated. Cholesterol originates predominantly by de novo…
TSH-Producing Adenomas
FIGURE 17-1. The significant increase in reported cases of pituitary thyrotropin (TSH)-producing adenoma in the decade from 1989 to 1999, when ultrasensitive TSH assay and direct methods for free thyroid…
Hormone Signaling Via G Protein–Coupled Receptors
FIGURE 5-1. Schematic of G protein–coupled receptor (GPCR) structures. Top panel represents a subclass I rhodopsin/neurotransmitter GPCR. Middle panel represents a subclass II glucagon–related receptor. Bottom panel represents a subclass…
Adrenocortical Carcinoma
FIGURE 106-1. CT after contrast media of 8.5 cm in homogeneous ACC of the left adrenal gland (white arrow) and liver metastases (black arrows). (Image provided by W. Kenn, Dept….
