Basic Mycology
Collection site Comments Abscesses, subcutaneous sites Aspirate abscess; sample base of subcutaneous lesions Blood Use maximum amount of blood recommended for the system being used Bone marrow Pediatric Isolator™ recommendedb…
Dermatophytosis (Tinea) and Other Superficial Fungal Infections
Condition Presentation Differential diagnosis Tinea pedis Interdigital: scaling, fissuring, maceration, erosions, hyperhidrosis, pruritus, odor Candidiasis, erythrasma, bacterial infection, psoriasis, contact dermatitis, dyshidrotic eczema, Reiter’s syndrome Moccasin: fine silvery scales with…
Diagnostic Radiology
Radiological finding Fungus Granulomas or solid enhancing lesions Aspergillus, Cryptococcus, Histoplasma, Candida, Paracoccidioides Abscesses Aspergillus, Blastomyces (epidural), Coccidioides, Cryptococcus, Candida, dematiaceous fungi, Pseudallescheria boydii (Scedosporium apiospermum) Parenchymal/leptomeningeal nodules; pseudocysts Cryptococcus…
Diagnostic Histopathology
Fig. 4.1 Budding cell of Blastomyces dermatitidis. Note that the daughter cell is almost as large as the mother cell and still connected by a pore. H&E hematoxylin and eosin….
Coccidioidomycosis
Coccidioides was originally described as noted above as one species, C. immitis. More recently, two genetically distinct populations of Coccidioides have been described, C. immitis and Coccidioides posadasii, correlating to…
Blastomycosis
Fig. 16.1 The mycelial phase of B. dermatitidis (left) produces no unique characteristics which allow organism identification. As a yeast (right), B. dermatitidis has characteristic thick walled, multinucleated cells with…
Cryptococcosis
Serotype Species and varieties Molecular types A C. neoformans var. grubii VN I, VN II, VN B B C. gattii VG I, VG II, VG III, VG IV C C….
Fungal Infections of Implantation (Chromoblastomycosis, Mycetoma, Entomophthoramycosis, and Lacaziosis)
Disease Affected population Clinical manifestations Laboratory diagnosis Treatment Chromoblastomycosis (also called chromomycosis, verrucous dermatitis, figueiraa) Usually in men aged 30–50 who work as farm laborers, lumberjacks, or sellers of farm…
Sporotrichosis
Fig. 20.1 Microscopic view of the mold form of Sporothrix schenckii grown at 25 ℃ on Sabouraud dextrose agar. Note the thin septate hyphae with conidiophores that bear oval conidia that…
Antifungal Agents
Fig. 7.1 Representative structures of systemic antifungal agents Limited absorption of the drug at elevated gastric pH. Lack of an intravenous (IV) formulation. Requirement for extensive cytochrome P450 biotransformation before…
