Repair and Chromosomal Translocations
Fig. 1 The balance of DNA damage and DNA repair determines the stability of a genome It is becoming more and more apparent that the fine tuning of genomic stability is…
as Models of Mitotic Fidelity
Wild-type Aneuploid strains Method Notes Haploid (1n)16 chr Monosomies (n − 1) Centromere silencing (CS) Inviable Disomies (n + 1) CS, Chromosome transfer (CT) and meiois of 3n or 5n (RM) 12 disomes from…
Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development
Fig. 1 Numbers of somatic structural variants (SV) and single nucleotide variants (SNVs) identified in prostate (Berger et al. 2011) and colorectal cancer (Bass et al. 2011) Insight into structural genomic…
Dysfunction, Chromosomal Instability and Cancer
Fig. 1 Telomere-DNA is an evolutionarily conserved GT-rich repetitive sequence. Basically all eukaryotes use GT-rich repetitive sequences at the ends of their chromosomes (telomeres). Despite considerable variation in telomere length and…
of Chromosomal Aberrations in Solid Tumors
Fig. 1 Schematic illustration of commonly observed numerical and structural chromosome alterations identified in solid tumors, and the methodologies capable of their detection. Detection of an alteration, however, is not necessarily…
of Aneuploidy in Cancer: Transcriptome and Beyond
Fig. 1 Karyotype aberrations. Doubling the karyotype results in polyploidy, whereas loss or gain of one entire chromosome results in whole chromosome aneuploidy. Unbalanced structural rearrangements such as gain or loss…
of Chromosomal Instability
Fig. 1 Summary of the major mechanisms causing CIN in human cancer cells. The major defects leading to chromosome missegregation in human cancer cells are a premature loss of sister chromatid…
Modelling: What Have Mouse Models for Chromosome Instability Taught Us?
Fig. 1 Schematic overview of various genes targeted to provoke CIN in vivo 3 In Vivo Consequences of CIN In the last two decades, a large number of mouse models for…
Instability and Disease Prognostication
Fig. 1 a HDAC2 and TXNL1 immunohistochemical detection in colorectal cancer specimens based on a tissue microarray. Image examples are given at 800-fold magnification. b Tissue-microarray-based immunohistochemical evaluation of HDAC2 and…
