Cancer of Unknown Primary: The Pathologist’s Approach
Fig. 7.1 Frequencies of the CUP syndrome in Germany (The data was made available from the Robert Koch Institute (see [3]) and adapted from [2]). (a) Absolute CUP numbers for…
Favorable Subsets Among Cancers of Unknown Primary
CUP subset Diagnosticsa Pathology Treatment options Solitary metastatic disease Positron emission tomography (PET) Variable Surgery followed by radiotherapy or chemoradiotherapy adjuvant chemotherapy Neoadjuvant chemotherapy + surgery Definitive radiotherapy or chemoradiotherapy…
Concepts of Radiotherapy in Cancer of Unknown Primary
(1) RadioOnkologie und Strahlentherapie, UniversitätsKlinikum Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany David Krug Email: david.krug@med.uni-heidelberg.de 9.1 Curative Treatment Concepts 9.1.1 Axillary Cancer of Unknown Primary 9.1.1.1 Introduction…
Epidemiology, Risk Factors, and Survival in CUP: Pointers to Disease Mechanisms
Metastatic sites Start of follow-up 0 months+ 3 months+ 7 months+ Cases (%) Cancer deaths Median survival Cases (%) Cancer deaths Median survival Cases (%) Cancer deaths Median survival Lymph…
Prognostic Factors and Their Role in the Management of CUP
Citation Study population Survival data, selected prognostic factors, comments Altman and Cadman (1986) [30] 1539 cases from a single center (USA), 1922–1981 Median OS 5 months. 56 % of cases…
The Radiologist’s Approach to CUP
Fig. 6.1 A 43-year-old male patient with multiple endocrine neoplasia syndrome (MEN) type 1. On contrast-enhanced MRI a singular mass in the pancreatic head was observed suspicious for a neuroendocrine…
Novel Diagnostic and Therapeutic Strategies in the Management of Patients with Cancers of Unknown Primary Site
History and physical examination Laboratory tests: CBC, CMP, LDH, urine analysis, PSA in men Computerized tomographic (CT) scans of the chest, abdomen, pelvis Positron emission tomography (PET) scan in selected…
Future Directions
© Springer International Publishing Switzerland 2016Alwin Krämer and Harald Löffler (eds.)Cancer of Unknown Primary10.1007/978-3-319-22581-4_12 12. Future Directions Alwin Krämer1 and Harald Löffler1 (1) Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and University of Heidelberg,…
Biologic Features of CUP
Fig. 3.1 Hypothetical explanations why there is no primary lesion detectable in CUP. See text for details (Figure adapted from Löffler et al. [4]) The primary tumor is present, but…
Treatment of Disseminated CUP
Resectable disease(“oligometastatic”) Involvement of one lymph node area only (e.g., inguinal nodes), solitary lesions, resectable liver metastases Cervical node metastases with squamous or undifferentiated histology Strong resemblance to head and…
