Fertility Preservation in the Pediatric Setting
Agent Cumulative dose associated with azoospermia Cyclophosphamide >5–7.5 g/m2 associated with abnormal semen parameters, >19 g/m2 consistently result in azoospermia Ifosfamide >60 g/m2 Procarbazine >4 g/m2 Busulfan >600 mg/m2 Melphalan…