Stage Immune phenotype Target Early precursor HLA-DR, TdT, cCD22, CD79a, CD19 CD19 Blinatumomab Intermediate precursor (common) HLA-DR, TdT, cCD22, CD79a, CD19, CD10, CD20 (variable) CD19 Blinatumomab CD20 Rituximab, ofatumumab Late…
62. Scursoni AM, Galluzzo L, Camarero S, Pozzo N, Gabri MR, de Acosta CM, et al. Detection and characterization of N-glycosylated gangliosides in Wilms tumor by immunohistochemistry. Pediatr Dev Pathol….
Mechanism Ag Short description of function Ab name Results of earlier trials Ongoing clinical trials mAbs targeting proteins involved in myeloma cell adhesion CS1 See text Elotuzumab Syndecan-1 (CD138) Cell…
1 Shared/self-/differentiation TAAs (e.g., Melan-A, PSA, CEA) 2 Shared/self-/cancer testis or germinal TAAs (e.g., MAGE, NY-ESO-1) 3 Universal TAAs (e.g., survivin, hIERI) 4 Mutated, unique TAAs The TAAs recognized by…
