Species V segment usage Common VγVδ usage V(d) J diversity Day of exportation from the embryonic thymus Distribution Mouse Vγ1 Vγ1Vδ6.3 (liver) High From E18 onward Spleen, liver Vγ4 High…
Fig. 21.1 PDT induced effects. In tumors, cells loaded with PS upon excitation generate ROS species which leads to predominantly apoptotic and necrotic cell deaths. Tumor cell death is accompanied…
Fig. 3.1 Biomarkers have to be very prognostic for the specific physiopathological conditions inherent with the pathology. Being the chronicity of inflammation, the base for the genesis and the progression…
Fig. 23.1 Structure of 5T4 molecules. Human and mouse 5T4 analyzed by a homology modeling approach using the variable lymphocyte receptor A29 (PDB entry 2o6q) and energy minimized to produce…
Groups of tumor antigens Antigens Cancer type Cancer testis (CT) MAGE1-3 and -6 Melanoma, breast, head/neck HAGE, GAGE, NY – ESO – 1, BAGE, XAGE Bladder, gastric and lung, head/neck,…
Ag category Examples Expression in cancer Tissue differentiation Ags Mclan-A/MART-1, gp100, tyrosinase, TRP-1, TRP-2 Melanoma PSA Prostate carcinoma Prostate-specific membrane Ag (PSMA) Prostate carcinoma MUC-1 Particular adenocarcinomas MUC-16 (CA-125) Mainly…
Fig. 22.1 Simplified scheme of tumor progression. During progression, cancer cells recruit inflammatory cells and “educate” their phenotype (in the case of macrophages, from M1 to M2). The phenotype abbreviated…
Radionuclide T 1/2 (h)a Emissionsb Emax (keV)c Range max in soft tissue (mm)c Usual labeling method Technetium-99 m 6.0 γ 140 Direct labeling or N2S2 or N3S complexes Indium-111 67…
Cancer type TLRs expressed Basal cell carcinoma TLR7 Breast cancer TLR2, 3, 4, 5, 7, and 9 Brain cancer TLR2 and 4 Colorectal cancer TLR2, 3, 4, 5, 7, and…
Fig. 15.1 Tumor growth, CTL activity, IFN-γ expression; a comparison in B cell-depleted mice (BCDM), B cell-reconstituted BCDM, and immunocompetent wild-type (WT) mice. Mice were subcutaneously injected with 106 EMT-6…
