Adjuvant Biologic Agents for Breast Cancer

Jun 4, 2017 by in ONCOLOGY Comments Off on Adjuvant Biologic Agents for Breast Cancer

  Number of patients DFS/RFS HR (95 %CI or p value) OS Cardiotoxicity Comments NSABP B31/N9831 [35] 5,548 0.60 (0.53–0.68) 0.63 (0.54–0.73) 4.1 % The N9831 also included a sequential…

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Adjuvant Therapy for Breast Cancer: Hormonal Therapy

Jun 4, 2017 by in ONCOLOGY Comments Off on Adjuvant Therapy for Breast Cancer: Hormonal Therapy

Toxicity HR Endometrial cancer 3.28 Pulmonary embolism 2.15 Deep venous thrombosis 1.44 Bone fractures 0.68 In the most recent Oxford Overview Analysis, there was a nonsignificant increase in stroke deaths…

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Adjuvant Chemotherapy in Breast Cancer

Jun 4, 2017 by in ONCOLOGY Comments Off on Adjuvant Chemotherapy in Breast Cancer

Regimen Dose Cycle duration No cycles Notes Reference Non-anthracycline containing Oral CMF Cyclophosphamide (100 mg/m2, PO) d1 to 14 Methotrexate (40 mg/m2) d1, 8 5-Fluorouracil (500 mg/m2) d1, 8 q4…

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The Initial Consultation: Malignant Disease

Jun 4, 2017 by in ONCOLOGY Comments Off on The Initial Consultation: Malignant Disease

Fig. 7.1 (a, b) The Advocate Christ Medical Center’s multidisciplinary oncology breast clinic’s intake form The history of present illness should note the means of how the cancer was initially…

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Operative Management of Metastatic Breast Cancer

Jun 4, 2017 by in ONCOLOGY Comments Off on Operative Management of Metastatic Breast Cancer

© Springer Science+Business Media New York 2015Adam I. Riker (ed.)Breast Disease10.1007/978-1-4939-1145-5_16 16. Operative Management of Metastatic Breast Cancer Hannah W. Hazard1   (1) Department of Surgery, Health Sciences Center – South, West Virginia University School of Medicine,…

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Current Management of Nipple Discharge

Jun 4, 2017 by in ONCOLOGY Comments Off on Current Management of Nipple Discharge

Fig. 6.1 Algorithm for the management of nipple discharge. *If patient plans future breastfeeding, selective duct excision is preferred over major duct excision The characteristics of the discharge should be…

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Breast-Conserving Therapy for Breast Cancer

Jun 4, 2017 by in ONCOLOGY Comments Off on Breast-Conserving Therapy for Breast Cancer

Fig. 13.1 Lumpectomy versus mastectomy (From McGuire et al. [5]) Keystone Trials Over the past 50 years, patient education, screening, and early detection with advancements in mammography, ultrasound, magnetic resonance…

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Current Management of Ductal Carcinoma In Situ (DCIS)

Jun 4, 2017 by in ONCOLOGY Comments Off on Current Management of Ductal Carcinoma In Situ (DCIS)

Fig. 11.1 (a) Low-grade ductal carcinoma in situ (grade 1): low-grade monomorphic nuclei, inconspicuous nucleoli, diffuse chromatin, cells maintain polarity around gland-like spaces, no comedo necrosis. (b) Intermediate-grade ductal carcinoma…

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The Emerging Role of Prophylactic Mastectomy

Jun 4, 2017 by in ONCOLOGY Comments Off on The Emerging Role of Prophylactic Mastectomy

Patient  Young age  White race  Private insurance  Family history of breast cancer Tumor  Infiltrating lobular histology  Multicentric disease  Tumor size Treatment  BRCA testing  MRI  Breast reconstruction  Facility type Reasons for…

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